Immune checkpoint inhibitors in the treatment of advanced mucosal melanoma.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2017-09-01 Epub Date: 2017-10-04 DOI:10.2217/mmt-2017-0014

James C Kuo

引用次数: 8

Abstract

Immunotherapy with immune checkpoint inhibitors is the standard of care in the treatment of advanced melanoma. Treatment outcome of these agents is less defined for the rare subtype of mucosal melanoma. In this single-institutional case series, the objective response rate was low at 11.8%, but durable response was seen, including a complete response to first-line ipilimumab and to second-line pembrolizumab. Survival remained poor; at the median follow-up of 10.1 months, the median progression-free survival and overall survival were 3.1 and 8.8 months respectively. Nevertheless, among the few responders, survival of up to 56+ months was observed. Other treatment strategies need to be explored to improve treatment outcome for this rare subtype.

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免疫检查点抑制剂治疗晚期粘膜黑色素瘤。

免疫检查点抑制剂的免疫疗法是治疗晚期黑色素瘤的标准护理。对于罕见的粘膜黑色素瘤亚型，这些药物的治疗效果尚不明确。在这个单一机构的病例系列中，客观缓解率很低，为11.8%，但可以看到持久的缓解，包括对一线伊匹单抗和二线派姆单抗的完全缓解。生存率仍然很低;中位随访10.1个月时，中位无进展生存期和总生存期分别为3.1个月和8.8个月。然而，在少数应答者中，观察到的生存期长达56个月以上。需要探索其他治疗策略来改善这种罕见亚型的治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.