Lymph node dissection for melanoma: where do we stand?

IF 1 Q4 ONCOLOGY

Melanoma Management Pub Date : 2017-03-01 Epub Date: 2017-03-03 DOI:10.2217/mmt-2016-0023

Madalyn G Neuwirth, Edmund K Bartlett, Giorgos C Karakousis

引用次数: 1

Abstract

The extent and timing of regional lymphadenectomy and its role in patients with clinically localized primary melanoma has been the subject of considerable debate. While therapeutic lymphadenectomy for clinically positive nodes is uniformly accepted, the benefit of regional lymphadenectomy in patients with clinically uninvolved lymph nodes potentially harboring micrometastatic disease is less clear. Efforts to better select patients for complete regional lymphadenectomy after sentinel lymph node biopsy are underway. The future holds the promise of more stringent selection criteria and perhaps the identification of subgroups of patients for which a therapeutic benefit may be realized. Moreover, novel sensitive radiological techniques for detecting in vivo micrometastatic nodal disease may improve surgical precision, further decreasing potential morbidities of lymphadenectomy.

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淋巴结清扫治疗黑色素瘤:我们站在哪里?

局部淋巴结切除术的范围和时间及其在临床上局限性原发性黑色素瘤患者中的作用一直是相当有争议的主题。虽然对临床阳性淋巴结进行治疗性淋巴结切除术已被普遍接受，但对临床未累及淋巴结可能存在微转移性疾病的患者进行局部淋巴结切除术的益处尚不清楚。在前哨淋巴结活检后，更好地选择患者进行完全区域淋巴结切除术的努力正在进行中。未来有希望有更严格的选择标准，也许可以确定治疗益处可能实现的患者亚组。此外，用于检测体内微转移淋巴结疾病的新型敏感放射技术可能提高手术精度，进一步降低淋巴结切除术的潜在发病率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Melanoma Management ONCOLOGY-

CiteScore

5.10

自引率

0.00%

发文量

审稿时长

13 weeks

期刊介绍： Skin cancer is on the rise. According to the World Health Organization, 132,000 melanoma skin cancers occur globally each year. While early-stage melanoma is usually relatively easy to treat, once disease spreads prognosis worsens considerably. Therefore, research into combating advanced-stage melanoma is a high priority. New and emerging therapies, such as monoclonal antibodies, B-RAF and KIT inhibitors, antiangiogenic agents and novel chemotherapy approaches hold promise for prolonging survival, but the search for a cure is ongoing. Melanoma Management publishes high-quality peer-reviewed articles on all aspects of melanoma, from prevention to diagnosis and from treatment of early-stage disease to late-stage melanoma and metastasis. The journal presents the latest research findings in melanoma research and treatment, together with authoritative reviews, cutting-edge editorials and perspectives that highlight hot topics and controversy in the field. Independent drug evaluations assess newly approved medications and their role in clinical practice. Key topics covered include: Risk factors, prevention and sun safety education Diagnosis, staging and grading Surgical excision of melanoma lesions Sentinel lymph node biopsy Biological therapies, including immunotherapy and vaccination Novel chemotherapy options Treatment of metastasis Prevention of recurrence Patient care and quality of life.