Nonalcoholic fatty liver disease and hepatocellular carcinoma.

IF 1.2 Q4 ONCOLOGY

Hepatic Oncology Pub Date : 2017-07-01 Epub Date: 2017-10-30 DOI:10.2217/hep-2017-0013

Stephanie Klein, Jean-François Dufour

引用次数: 8

Abstract

Hepatocellular carcinoma (HCC) in patients with nonalcoholic fatty liver disease is becoming more common globally. The incidence of HCC due to nonalcoholic steatohepatitis in comparison to other etiologies is increasing. This is due to the pandemic of obesity and diabetes mellitus, two important risk factors for HCC. HCC arising in this context occurs in about 40% of the cases in a liver which is not yet cirrhotic. This has implications regarding the population which should be enrolled in an HCC surveillance program and regarding the treatment options. Surgery is more frequently contemplated in patients with HCC and no cirrhosis. However, patients with nonalcoholic steatohepatitis-induced HCC have frequent co-morbidities which have to be taken into account when developing a management strategy. Interestingly, these patients are frequently on medications which have been suggested to decrease the risk to develop HCC.

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非酒精性脂肪性肝病和肝细胞癌。

非酒精性脂肪性肝病患者的肝细胞癌(HCC)在全球变得越来越普遍。与其他病因相比，非酒精性脂肪性肝炎引起的HCC发病率正在增加。这是由于肥胖和糖尿病的流行，这是HCC的两个重要危险因素。在这种情况下，大约40%的HCC发生在尚未肝硬化的肝脏中。这对应该纳入HCC监测计划的人群和治疗方案具有启示意义。肝细胞癌且无肝硬化的患者更常考虑手术。然而，非酒精性脂肪性肝炎诱导的HCC患者经常有合并症，在制定治疗策略时必须考虑到这一点。有趣的是，这些患者经常服用被建议降低发生HCC风险的药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hepatic Oncology ONCOLOGY-

CiteScore

0.40

自引率

0.00%

发文量

审稿时长

13 weeks

期刊介绍： Primary liver cancer is the sixth most common cancer in the world, and the third most common cause of death from malignant disease. Traditionally more common in developing countries, hepatocellular carcinoma is becoming increasingly prevalent in the Western world, primarily due to an increase in hepatitis C virus infection. Emerging risk factors, such as non-alcoholic fatty liver disease and obesity are also of concern for the future. In addition, metastatic tumors of the liver are more common than primary disease. Some studies report hepatic metastases in as many as 40 to 50% of adult patients with extrahepatic primary tumors. Hepatic Oncology publishes original research studies and reviews addressing preventive, diagnostic and therapeutic approaches to all types of cancer of the liver, in both the adult and pediatric populations. The journal also highlights significant advances in basic and translational research, and places them in context for future therapy. Hepatic Oncology provides a forum to report and debate all aspects of cancer of the liver and bile ducts. The journal publishes original research studies, full reviews and commentaries, with all articles subject to independent review by a minimum of three independent experts. Unsolicited article proposals are welcomed and authors are required to comply fully with the journal''s Disclosure & Conflict of Interest Policy as well as major publishing guidelines, including ICMJE and GPP3.