Whole Genome Sequencing of Klebsiella pneumoniae Strain Unravels a New Model for the Development of Extensive Drug Resistance in Enterobacteriaceae.

Q3 Immunology and Microbiology

Open Microbiology Journal Pub Date : 2018-06-29 eCollection Date: 2018-01-01 DOI:10.2174/1874285801812010195

Mubarak Alfaresi

引用次数: 5

Abstract

Introduction: Increased incidence of carbapenem-resistant Enterobacteriaceae (CRE) has been reported worldwide. The WHO warns about the imminent risk to global health if the spread of resistant bacteria is not contained.

Materials and methods: Here, single molecule real time sequencing was used to analyse the whole genome and resistome of SKGH01, a strain of Klebsiella pneumoniae .

Results and discussions: The data showed that SKGH01 was resistant to all commercially available antibiotics. A complete account of extensively drug-resistant (XDR) CRE at a genomic level and the entire location map of all antibiotic resistance components are here presented. Additionally, this work proposes a model of XDR acquisition in Enterobacteriaceae.

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肺炎克雷伯菌全基因组测序揭示了肠杆菌科广泛耐药发展的新模式。

导读:据报道，全球范围内碳青霉烯耐药肠杆菌科(CRE)的发病率有所增加。世界卫生组织警告说，如果不控制耐药细菌的传播，全球健康将面临迫在眉睫的风险。材料与方法:本研究采用单分子实时测序技术对一株肺炎克雷伯菌SKGH01的全基因组和抗性组进行了分析。结果与讨论:数据显示，SKGH01对所有市售抗生素均具有耐药性。在基因组水平上，广泛耐药(XDR) CRE的完整描述和所有抗生素耐药成分的整个位置图在这里提出。此外，本工作提出了肠杆菌科XDR获取模型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Microbiology Journal Immunology and Microbiology-Immunology and Microbiology (all)

CiteScore

1.80

自引率

0.00%

发文量

期刊介绍： The Open Microbiology Journal is a peer-reviewed open access journal which publishes research articles, reviews/mini-reviews, case studies, guest edited thematic issues and short communications/letters covering theoretical and practical aspects of Microbial systematics, evolutionary microbiology, immunology, virology, parasitology , bacteriology, mycology, phycology, protozoology, microbial ecology, molecular biology, microbial physiology, biochemistry, microbial pathogenesis, host-microbe interaction, systems microbiology, synthetic microbiology, bioinformatics. The Open Microbiology Journal , a peer-reviewed journal, is an important and reliable source of current information on developments in the field. The emphasis will be on publishing quality papers rapidly and freely available to researchers worldwide.