Accessing Expert-Curated Pharmacological Data in the IUPHAR/BPS Guide to PHARMACOLOGY

Q1 Biochemistry, Genetics and Molecular Biology

Current protocols in bioinformatics Pub Date : 2018-04-09 DOI:10.1002/cpbi.46

Joanna L. Sharman, Simon D. Harding, Christopher Southan, Elena Faccenda, Adam J. Pawson, Jamie A. Davies, NC-IUPHAR

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引用次数: 10

Abstract

The IUPHAR/BPS Guide to PHARMACOLOGY is an expert-curated, open-access database of information on drug targets and the substances that act on them. This unit describes the procedures for searching and downloading ligand-target binding data and for finding detailed annotations and the most relevant literature. The database includes concise overviews of the properties of 1,700 data-supported human drug targets and related proteins, divided into families, and 9,000 small molecule and peptide experimental ligands and approved drugs that bind to those targets. More detailed descriptions of pharmacology, function, and pathophysiology are provided for a subset of important targets. The information is reviewed regularly by expert subcommittees of the IUPHAR Committee on Receptor Nomenclature and Drug Classification. A new immunopharmacology portal has recently been added, drawing together data on immunological targets, ligands, cell types, processes and diseases. The data are available for download and can be accessed computationally via Web services. © 2018 by John Wiley & Sons, Inc.

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在IUPHAR/BPS药理学指南中访问专家策划的药理学数据

IUPHAR/BPS药理学指南是一个专家策划的、开放获取的关于药物靶标及其作用物质的信息数据库。本单元描述了搜索和下载配体-靶标结合数据以及查找详细注释和最相关文献的过程。该数据库包括1700个数据支持的人类药物靶点和相关蛋白质的简要概述，分为家族，9000个小分子和肽实验配体以及与这些靶点结合的批准药物。更详细的描述药理学，功能和病理生理学提供了一个子集的重要目标。这些信息由IUPHAR受体命名法和药物分类委员会的专家小组委员会定期审查。最近增加了一个新的免疫药理学门户网站，汇集了免疫靶点、配体、细胞类型、过程和疾病的数据。这些数据可供下载，并且可以通过Web服务进行计算访问。©2018 by John Wiley &儿子,Inc。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Current protocols in bioinformatics Biochemistry, Genetics and Molecular Biology-Biochemistry

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