Neural functional correlates of emotional processing in patients with first-episode psychoses: an activation likelihood estimation (ALE) meta-analysis.

IF 0.8 4区医学 Q4 NEUROSCIENCES

Archives Italiennes De Biologie Pub Date : 2018-07-01 DOI:10.12871/00039829201811

A Del Casale, C Rapinesi, G D Kotzalidis, S Ferracuti, A Padovano, C Grassi, G Sani, P Girardi, M Pompili

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引用次数: 7

Abstract

Background: Early emotional recognition impairment characterises rst-episode psychoses (FEP) and remains stable thereafter. Patients with FEP consistently show brain activation changes during emotional processing in functional neuroimaging studies.

Aim and methods: To identify and compare cerebral activation correlates of FEP patients and healthy controls (HCs) during emotional task performances, we performed an Activation Likelihood Estimation (ALE) meta-analysis of peer-reviewed functional magnetic resonance imaging (fMRI) studies.

Results: Five studies included 71 patients with FEP and 75 HCs. Within-group analyses showed that HCs activated during emotional task performance the bilateral inferior parietal lobule (BAs 39 and 40), left inferior frontal gyrus (BAs 9 and 47), right amygdala, left middle frontal gyrus (BA 9), right cingulate gyrus (BA 32), and right middle temporal gyrus (BA 21). FEP activations correlating with emotional tasks included the right cuneus (BA 17) and right angular gyrus (BA 39).

Conclusions: During emotional task performance, FEP patients fail to activate an extensive brain network comprising emotional processing-related areas, including both cortical and subcortical areas.

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首发精神病患者情绪处理的神经功能相关性:激活似然估计(ALE)荟萃分析。

背景:早期情绪识别障碍是首发精神病(FEP)的特征，此后保持稳定。在功能性神经影像学研究中，FEP患者在情绪处理过程中始终表现出大脑激活变化。目的和方法:为了识别和比较FEP患者和健康对照(hc)在情绪任务表现中的大脑激活相关因素，我们对同行评审的功能磁共振成像(fMRI)研究进行了激活似然估计(ALE)荟萃分析。结果:5项研究包括71例FEP患者和75例hcc患者。组内分析显示，在情绪任务执行过程中，HCs被激活的区域包括双侧顶叶下小叶(ba39和40)、左侧额下回(ba9和47)、右侧杏仁核、左侧额中回(ba9)、右侧扣带回(ba32)和右侧颞中回(ba21)。与情绪任务相关的FEP激活包括右楔叶(ba17)和右角回(ba39)。结论:在情绪任务执行过程中，FEP患者未能激活包含情绪处理相关区域的广泛大脑网络，包括皮层和皮层下区域。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives Italiennes De Biologie 医学-神经科学

CiteScore

2.10

自引率

30.00%

发文量

审稿时长

>12 weeks

期刊介绍： Archives Italiennes de Biologie - a Journal of Neuroscience- was founded in 1882 and represents one of the oldest neuroscience journals in the world. Archives publishes original contributions in all the fields of neuroscience, including neurophysiology, experimental neuroanatomy and electron microscopy, neurobiology, neurochemistry, molecular biology, genetics, functional brain imaging and behavioral science. Archives Italiennes de Biologie also publishes monographic special issues that collect papers on a specific topic of interest in neuroscience as well as the proceedings of important scientific events. Archives Italiennes de Biologie is published in 4 issues per year and is indexed in the major collections of biomedical journals, including Medline, PubMed, Current Contents, Excerpta Medica.