Acute Lidocaine Toxicity; a Case Series.

Emergency Pub Date : 2018-01-01 Epub Date: 2018-06-16

Mitra Rahimi, Mahboubeh Elmi, Hossein Hassanian-Moghaddam, Nasim Zamani, Kambiz Soltaninejad, Reza Forouzanfar, Shahin Shadnia

{"title":"Acute Lidocaine Toxicity; a Case Series.","authors":"Mitra Rahimi, Mahboubeh Elmi, Hossein Hassanian-Moghaddam, Nasim Zamani, Kambiz Soltaninejad, Reza Forouzanfar, Shahin Shadnia","doi":"","DOIUrl":null,"url":null,"abstract":"Introduction: Parenteral form of lidocaine is the best-known source of lidocaine poisoning. This study aimed to evaluate the characteristics of acute lidocaine toxicity .Methods: In this retrospective cross-sectional study, demographics, clinical presentation, laboratory findings, and outcome of patients intoxicated with lidocaine (based on ICD10 codes) admitted to Loghman Hakim Hospital, during April 2007 to March 2014 were analyzed.Results: 30 cases with the mean age of 21.83 ± 6.57 year were studied (60% male). All subjects had used either 6.5% lidocaine spray or 2% topical formulations of lidocaine. The mean consumed dose of lidocaine was 465 ± 318.17 milligrams. The most frequent clinical presentations were nausea and vomiting (50%), seizure (33.3%), and loss of consciousness (16.7%). 22 (73.3%) cases had normal sinus rhythm, 4 (13.3%) bradycardia, 2 (6.7%) ventricular tachycardia, and 2 (6.7%) had left axis deviation. 11 (36.6%) cases were intubated and admitted to intensive care unit (ICU) for 6.91 ± 7.16 days. Three patients experienced status epilepticus that led to cardiac arrest, and death (all cases with suicidal intention).Conclusion: Based on the results of this study, most cases of topical lidocaine toxicity were among < 40-year-old patients with a male to female ratio of 1.2, with suicidal attempt in 90%, need for intensive care in 36.6%, and mortality rate of 10%.","PeriodicalId":11681,"journal":{"name":"Emergency","volume":"6 1","pages":"e38"},"PeriodicalIF":0.0000,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/af/72/emerg-6-e38.PMC6036540.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Emergency","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2018/6/16 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction: Parenteral form of lidocaine is the best-known source of lidocaine poisoning. This study aimed to evaluate the characteristics of acute lidocaine toxicity .

Methods: In this retrospective cross-sectional study, demographics, clinical presentation, laboratory findings, and outcome of patients intoxicated with lidocaine (based on ICD10 codes) admitted to Loghman Hakim Hospital, during April 2007 to March 2014 were analyzed.

Results: 30 cases with the mean age of 21.83 ± 6.57 year were studied (60% male). All subjects had used either 6.5% lidocaine spray or 2% topical formulations of lidocaine. The mean consumed dose of lidocaine was 465 ± 318.17 milligrams. The most frequent clinical presentations were nausea and vomiting (50%), seizure (33.3%), and loss of consciousness (16.7%). 22 (73.3%) cases had normal sinus rhythm, 4 (13.3%) bradycardia, 2 (6.7%) ventricular tachycardia, and 2 (6.7%) had left axis deviation. 11 (36.6%) cases were intubated and admitted to intensive care unit (ICU) for 6.91 ± 7.16 days. Three patients experienced status epilepticus that led to cardiac arrest, and death (all cases with suicidal intention).

Conclusion: Based on the results of this study, most cases of topical lidocaine toxicity were among < 40-year-old patients with a male to female ratio of 1.2, with suicidal attempt in 90%, need for intensive care in 36.6%, and mortality rate of 10%.

Abstract Image

本刊更多论文

利多卡因急性毒性;a案例系列。

简介:注射形式的利多卡因是利多卡因中毒的最著名的来源。方法:回顾性分析2007年4月至2014年3月在Loghman Hakim医院住院的利多卡因中毒患者的人口统计学、临床表现、实验室结果和预后(基于ICD10代码)。结果:共30例，平均年龄21.83±6.57岁，其中男性占60%。所有受试者均使用6.5%利多卡因喷雾剂或2%利多卡因外用制剂。利多卡因平均用药剂量为465±318.17毫克。最常见的临床表现为恶心和呕吐(50%)、癫痫发作(33.3%)和意识丧失(16.7%)。窦性心律正常22例(73.3%)，心动过缓4例(13.3%)，室性心动过速2例(6.7%)，左轴偏曲2例(6.7%)。11例(36.6%)患者插管入ICU (ICU)，住院时间为6.91±7.16 d。3例患者出现癫痫持续状态，导致心脏骤停和死亡(所有病例均有自杀意图)。结论:本研究结果显示，局部利多卡因中毒病例以< 40岁患者为主，男女比例为1.2，有自杀企图者占90%，需要重症监护者占36.6%，死亡率为10%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Emergency EMERGENCY MEDICINE-

自引率

0.00%

发文量

审稿时长

8 weeks

期刊介绍： "Archives of Academic Emergency Medicine" is an international, Open Access, peer-reviewed, continuously published journal dedicated to improving the quality of care and increasing the knowledge in the field of emergency medicine by publishing high quality articles concerning emergency medicine and related disciplines. All accepted articles will be published immediately in order to increase its visibility and possibility of citation. The journal publishes articles on critical care, disaster and trauma management, environmental diseases, toxicology, pediatric emergency medicine, emergency medical services, emergency nursing, health policy and ethics, and other related topics. The journal supports the following types of articles: -Original/Research article -Systematic review/Meta-analysis -Brief report -Case-report -Letter to the editor -Photo quiz