Enumerating Antibiotic Susceptibility Patterns of Pseudomonas aeruginosa Isolated from Different Sources in Dhaka City.

Q3 Immunology and Microbiology

Open Microbiology Journal Pub Date : 2018-05-31 eCollection Date: 2018-01-01 DOI:10.2174/1874285801812010172

Mahmudullah Bhuiya, Mohammad K I Sarkar, Mehadi H Sohag, Hafij Ali, Chapol K Roy, Lutfa Akther, Abu F Sarker

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引用次数: 15

Abstract

Background: Pseudomonas aeruginosa is a ubiquitous free-living bacterium and is responsible for severe nosocomial infections, life-threatening infections in immune compromised persons. The bacterium, along with its natural resistance, can acquire resistance to many antibiotics by a variety of methods.

Method: Therefore, to compare the antibiotic sensitivity pattern of Pseudomonas aeruginosa, a total of seventeen isolates of P. aeruginosa were isolated from different sources; for example environmental sources, frozen food sources, clinical sources and medical waste materials. Isolates were confirmed to be P. aeruginosa by cultural and biochemical properties.

Result: The isolates were tested against seventeen commercially available antibiotics to observe the antibiotic susceptibility patterns. Imipenem and meropenem were the most potent antibiotics (100% sensitivity) followed by amikacin and piperacillin with maximum sensitivity. Among others, gentamicin, ciprofloxacin, levofloxacin and aztreonam were found to be fairly active. A good number of isolates were intermediately resistant to ceftriaxone. The rates of resistance to aztreonam, cefotaxime and ceftazidime were 11.76%, 82.35% and 5.88% respectively. Complete resistance was observed against penicillin, ampicillin, cefixime and cefpodoxime.

Conclusion: It can be concluded that the clinical isolates including isolate from medical waste, were multi-drug resistant than environmental and food isolates indicating the risk of transmission of resistance to the environmental isolates of P. aeruginosa.

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达卡市不同来源铜绿假单胞菌的抗生素敏感性分析。

背景:铜绿假单胞菌是一种普遍存在的自由生活细菌，在免疫功能低下的人群中造成严重的医院感染，危及生命的感染。这种细菌，连同它的天然耐药性，可以通过各种方法获得对许多抗生素的耐药性。方法:为了比较铜绿假单胞菌的药敏模式，从不同来源分离了17株铜绿假单胞菌;例如环境来源、冷冻食品来源、临床来源和医疗废物。经培养和生化特性鉴定，该菌株为铜绿假单胞菌。结果:对分离株进行了对17种市售抗生素的药敏试验。亚胺培南和美罗培南是最有效的抗生素(100%敏感性)，其次是阿米卡星和哌拉西林敏感度最高。其中庆大霉素、环丙沙星、左氧氟沙星和阿唑南被发现具有相当的活性。相当一部分菌株对头孢曲松具有中等耐药性。对氨曲南、头孢噻肟和头孢他啶的耐药率分别为11.76%、82.35%和5.88%。对青霉素、氨苄西林、头孢克肟和头孢多肟完全耐药。结论:包括医疗废弃物分离株在内的临床分离株对铜绿假单胞菌的多重耐药程度高于环境分离株和食品分离株，表明环境分离株对铜绿假单胞菌具有传播耐药风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Microbiology Journal Immunology and Microbiology-Immunology and Microbiology (all)

CiteScore

1.80

自引率

0.00%

发文量

期刊介绍： The Open Microbiology Journal is a peer-reviewed open access journal which publishes research articles, reviews/mini-reviews, case studies, guest edited thematic issues and short communications/letters covering theoretical and practical aspects of Microbial systematics, evolutionary microbiology, immunology, virology, parasitology , bacteriology, mycology, phycology, protozoology, microbial ecology, molecular biology, microbial physiology, biochemistry, microbial pathogenesis, host-microbe interaction, systems microbiology, synthetic microbiology, bioinformatics. The Open Microbiology Journal , a peer-reviewed journal, is an important and reliable source of current information on developments in the field. The emphasis will be on publishing quality papers rapidly and freely available to researchers worldwide.