Gene Therapy and Virotherapy of Gliomas.

Q2 Medicine

Progress in neurological surgery Pub Date : 2018-01-01 Epub Date: 2018-07-10 DOI:10.1159/000469685

Julius W Kim, Alan L Chang, J Robert Kane, Jacob S Young, Jian Qiao, Maciej S Lesniak

引用次数: 12

Abstract

Despite many recent advances in the management of gliomas, such as aggressive surgical resection, chemoradiotherapy, antiangiogenic therapy, and molecular targeted therapy, the survival of patients with high-grade neoplasms remains dismal. Gene therapy and oncolytic virotherapy have emerged as highly promising strategies for treatment of malignant brain tumors due to recent progress in understanding of the underlying cancer biology as well as improved techniques for genetic modification of potential therapeutics.

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神经胶质瘤的基因治疗和病毒治疗。

尽管最近在胶质瘤的治疗方面取得了许多进展，如积极的手术切除、放化疗、抗血管生成治疗和分子靶向治疗，但高级别肿瘤患者的生存率仍然很低。基因治疗和溶瘤病毒治疗已成为治疗恶性脑肿瘤的极具前景的策略，这是由于最近对潜在癌症生物学的理解取得了进展，以及对潜在治疗方法的基因修饰技术的改进。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Progress in neurological surgery Medicine-Surgery

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期刊介绍： Published since 1966, this series has become universally recognized as the most significant group of books serving neurological surgeons. Volumes feature contributions from distinguished international surgeons, who brilliantly review the literature from the perspective of their own personal experience. The result is a series of works providing critical distillations of developments of central importance to the theory and practice of neurological surgery.