[Application of magnetic iron oxide nanoparticles in magnetic resonance / photothermal dual-modal imaging].

药学学报 Pub Date : 2017-03-01

Dan-hua Huang, Xue-yong Qi, Yan-ru Ge, Song Shen

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引用次数: 0

Abstract

In this study, water-dispersible magnetic iron oxide (Fe3O4) nanoparticles were synthesized with solvothermal method. The nanoparticles were characterized with a transmission electron microscopy (TEM) and vibrating sample magnetometer (VSM). The in vitro magnetic resonance response and photothermal conversion characteristics of the nanoparticles were evaluated. In addition, the cellular uptake, cytotoxicity and biodistribution were studied. Finally, magnetic resonance/photothermal dual-modal imaging effect of the as-synthesized Fe3O4 nanoparticles was investigated in the tumor-bearing mice. The results showed that the obtained magnetic nanoparticles were uniform with a mean diameter of about 125 nm. Moreover, the superparamagnetic Fe3O4 nanoparticles showed remarkable magnetic resonance response and photothermal conversion properties. The results of cellular experiments showed that the cell viability was nearly 85% even the concentration of the nanoparticles was up to 1 000 μg·mL−1, an indicator of good biocompatibility. In addition, the nanoparticles could be taken up by the tumor cells and then located in the cytoplasm. After intravenous injection, the nanoparticles were tended to enrich in the tumor over time, which is helpful in achieving dual-modal magnetic resonance/photothermal imaging. In sum, the obtained Fe 3O4 nanoparticles showed great potential to be applied for multi-modal bio-imaging which may play an important role in the diagnosis of tumors.

本刊更多论文

磁性氧化铁纳米颗粒在磁共振/光热双峰成像中的应用

本研究采用溶剂热法合成了可水分散的磁性氧化铁纳米颗粒。采用透射电子显微镜(TEM)和振动样品磁强计(VSM)对纳米颗粒进行了表征。考察了纳米颗粒的体外磁共振响应和光热转化特性。并对其细胞摄取、细胞毒性和生物分布进行了研究。最后，研究了合成的Fe3O4纳米颗粒在荷瘤小鼠体内的磁共振/光热双模成像效果。结果表明，制备的磁性纳米颗粒均匀，平均直径约为125 nm。此外，超顺磁性Fe3O4纳米颗粒具有显著的磁共振响应和光热转换性能。细胞实验结果表明，即使纳米颗粒浓度达到1 000 μg·mL−1，细胞存活率仍接近85%，具有良好的生物相容性。此外，纳米颗粒可以被肿瘤细胞吸收并定位在细胞质中。经静脉注射后，随着时间的推移，纳米颗粒在肿瘤中趋于富集，这有助于实现双模磁共振/光热成像。综上所述，所获得的fe3o4纳米颗粒具有很大的应用潜力，可用于多模式生物成像，在肿瘤诊断中发挥重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

药学学报 Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

1.20

自引率

0.00%

发文量

期刊介绍： Acta Pharmaceutica Sinica B (APSB) is a bimonthly English peer-reviewed online journal in ScienceDirect, which publishes significant original research articles, communications and high quality reviews of recent advances. APSB encourages submissions from all areas of pharmaceutical sciences, including pharmacology, pharmaceutics, medicinal chemistry, natural products, pharmacognosy, pharmaceutical analysis and pharmacokinetics. APSB is a part of the series Acta Pharmaceutica Sinica, which was founded in 1953. The journal is co-published by Elsevier B.V., in association with the Institute of MateriaMedica, Chinese Academy of Medical Sciences and Chinese Pharmaceutical Association.