{"title":"[The protective effects of curcumin loaded mesoporous silica nanoparticles on rat cardiomyocytes].","authors":"Hui-ni Fu, Li Wu, Lian-wen Duan, Shu-zhi Lü","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Inhibition of apoptosis induced by oxidative stress is an effective way to reduce myocardial injury.\nIn this study, we used H2O2-stimulated rat cardiac myoblast cell line (H9c2) as an oxidative damage model.\nCurcumin (Cur) was chosen as a model drug and mesoporous silica nanoparticles (MSNs) were chosen as the\ncarrier to construct a Cur-loaded delivery system (Cur@MSNs) and to examine its protective effects against\noxidative damage. The MSNs guaranteed efficient loading and controlled release of Cur. Besides, the\nhydrophilicsilanol groups on the surface of MSNs promoted the Cur solubility in water and increased its\ncellular uptake amount, which improved the bioavailability of Cur. The results suggest that the Cur@MSNs\nwas pharmacologically active in the reduction of the oxidative damage of H9c2 cells. It was verified that a\ngreat decrease of reactive oxygen species was inducted by Cur@MSNs, which led to the protective effects\nagainst oxidative damage.</p>","PeriodicalId":35924,"journal":{"name":"药学学报","volume":"52 3","pages":"468-73"},"PeriodicalIF":0.0000,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"药学学报","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Inhibition of apoptosis induced by oxidative stress is an effective way to reduce myocardial injury.
In this study, we used H2O2-stimulated rat cardiac myoblast cell line (H9c2) as an oxidative damage model.
Curcumin (Cur) was chosen as a model drug and mesoporous silica nanoparticles (MSNs) were chosen as the
carrier to construct a Cur-loaded delivery system (Cur@MSNs) and to examine its protective effects against
oxidative damage. The MSNs guaranteed efficient loading and controlled release of Cur. Besides, the
hydrophilicsilanol groups on the surface of MSNs promoted the Cur solubility in water and increased its
cellular uptake amount, which improved the bioavailability of Cur. The results suggest that the Cur@MSNs
was pharmacologically active in the reduction of the oxidative damage of H9c2 cells. It was verified that a
great decrease of reactive oxygen species was inducted by Cur@MSNs, which led to the protective effects
against oxidative damage.
药学学报Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
CiteScore
1.20
自引率
0.00%
发文量
0
期刊介绍：
Acta Pharmaceutica Sinica B (APSB) is a bimonthly English peer-reviewed online journal in ScienceDirect, which publishes significant original research articles, communications and high quality reviews of recent advances. APSB encourages submissions from all areas of pharmaceutical sciences, including pharmacology, pharmaceutics, medicinal chemistry, natural products, pharmacognosy, pharmaceutical analysis and pharmacokinetics.
APSB is a part of the series Acta Pharmaceutica Sinica, which was founded in 1953. The journal is co-published by Elsevier B.V., in association with the Institute of MateriaMedica, Chinese Academy of Medical Sciences and Chinese Pharmaceutical Association.
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