[Crystal structure and crystal form stability of trelagliptin succinate].

药学学报 Pub Date : 2016-11-01

Jia-li Ye, Xin-bo Zhou, Su-xiang Wu, Meng-ying Sun, Jian-ming Gu, Xiu-rong Hu

引用次数: 0

Abstract

In order to investigate trelagliptin succinate’s stability in solution, recrystallization and suspension methods in polar solvent (mainly in water and 95% alcohol) were used to study the crystal form transformation of trelagliptin succinate. Single crystal X-ray diffraction, powder X-ray diffraction and thermalgravimetric analysis, and differential scanning calorimetry were used to characterize the structure of the solid state form before and after transformation. The results showed that trelagliptin succinate can easily convert to trelagliptin hemi-succinate mediated by solvent, especially by polar solvent, namely trelagliptin hemi-succinate is more stable than trelagliptin succinate in solution.

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[琥珀酸trelagliptin的晶体结构和晶型稳定性]。

为了考察琥珀酸trelag列汀在溶液中的稳定性，采用极性溶剂(主要是水和95%酒精)重结晶和悬浮法研究琥珀酸trelag列汀的晶型转变。采用单晶x射线衍射、粉末x射线衍射和热重分析、差示扫描量热法对相变前后固态形态的结构进行表征。结果表明，在溶剂，尤其是极性溶剂的介导下，曲列列汀易转化为曲列列汀半琥珀酸盐，即曲列列汀半琥珀酸盐比曲列列汀在溶液中更稳定。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

药学学报 Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

1.20

自引率

0.00%

发文量

期刊介绍： Acta Pharmaceutica Sinica B (APSB) is a bimonthly English peer-reviewed online journal in ScienceDirect, which publishes significant original research articles, communications and high quality reviews of recent advances. APSB encourages submissions from all areas of pharmaceutical sciences, including pharmacology, pharmaceutics, medicinal chemistry, natural products, pharmacognosy, pharmaceutical analysis and pharmacokinetics. APSB is a part of the series Acta Pharmaceutica Sinica, which was founded in 1953. The journal is co-published by Elsevier B.V., in association with the Institute of MateriaMedica, Chinese Academy of Medical Sciences and Chinese Pharmaceutical Association.