THE RELATIONSHIP OF THE IMMUNE AND METABOLIC DISORDERS DURING VARIOUS METHODS OF MULTICOMPONENT GENERAL ANESTHESIA IN LAPAROSCOPIC CHOLECYSTECTOMY.

Anesteziologiia i reanimatologiia Pub Date : 2016-11-01

A I Konoplya, S A Sumin, V P Gavrilyuk, L S Komissinskaya

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Abstract

Background: In addition to operating injury in the pathogenesis of immunological and metabolic disorders after surgical interventions anesthesia plays an important role.

The aim: to establish the relationship of the immune and metabolic disorders during various methods ofmulticomponent general anesthesia in conditions of laparoscopic cholecystectomy in patients with cholelithiasis.

Materials and methods: Under constant observation there were 68 women admitted to the hospital for surgical treatment of cholelithiasis. Patients were divided into 3 groups depending on multicomponent general anesthesia (halothane, propofol, sevoflurane). We determined the concentration of cytokines (TNFa, IL-la, IL-i/8, IL-4, IL-iRA, IL-2, IFNy), components of the complement system (C,, C3, C4, C, and C, factor H, C,-inhibitor), the activity of neutrophilsperipheral blood, the concentration of the products ofperoxidation, catalase, superoxide dismutase in blood plasma.

Results: The level of immune-inflammation and metabolic disorders in patients with cholelithiasis was higher in patients operated with the use of halothane. The use of sevoflurane has had the most positive effect on the studied indices.

Conclusion: The close correlation between the investigated immune and metabolic parameters on the background of the use of different schemes of multicomponent general anesthesia in patients with cholelithiasis have let to the conclusion that in the conditions of use of sevoflurane has the least place a "tension" immune and oxidative status.

本刊更多论文

腹腔镜胆囊切除术中多种全麻方式对免疫与代谢紊乱的影响。

背景:在手术损伤的发病机制中，除手术干预后的免疫和代谢紊乱外，麻醉也起着重要作用。目的:探讨胆石症患者腹腔镜胆囊切除术中不同麻醉方式下免疫与代谢紊乱的关系。材料与方法:在持续观察的情况下，68例住院接受手术治疗的女性胆石症患者。根据多组分全身麻醉(氟烷、异丙酚、七氟醚)将患者分为3组。我们测定了细胞因子(TNFa, IL-la, IL-i/8, IL-4, IL-iRA, IL-2, IFNy)的浓度，补体系统成分(C，， C3, C4, C和C，因子H, C，-抑制剂)，中性粒细胞外周血的活性，血浆中过氧化产物，过氧化氢酶，超氧化物歧化酶的浓度。结果:氟烷手术患者胆石症患者的免疫炎症和代谢紊乱水平较高。七氟醚的使用对研究指标的影响最为积极。结论:在胆石症患者使用不同方案的多组分全身麻醉的背景下，所研究的免疫和代谢参数之间的密切相关，得出结论:在使用七氟醚的情况下，免疫和氧化状态的“紧张”程度最小。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Anesteziologiia i reanimatologiia

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