The Outcome of Papillary Thyroid Cancer Associated with Graves' Disease: A Case Control Study.

IF 1.7 Q4 ENDOCRINOLOGY & METABOLISM
Journal of Thyroid Research Pub Date : 2018-05-08 eCollection Date: 2018-01-01 DOI:10.1155/2018/8253094
Riju Menon, C Gopalakrishnan Nair, Misha Babu, Pradeep Jacob, G Praveen Krishna
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引用次数: 0

Abstract

Introduction: Thyroidectomy is now a less popular therapeutic option for Graves' disease. The frequency of thyroid nodule and the cancer risk of these nodules accompanying Graves' disease are controversial. The outcome of thyroid cancers coexisting with Graves' disease is debated.

Study design: Designed as retrospective case control study of papillary thyroid cancers associated with Graves' disease and those with euthyroid background. Pathological characteristics and outcome of papillary thyroid cancers in the two groups were compared.

Results: The tumour characteristics did not differ significantly in the groups. The patients were followed for a mean period of 77.32 months and found significant incidences of disease progression in patients with papillary thyroid cancer associated with Graves' disease (p = 0.034; OR 2.747, CI 1.078-7.004). Disease progression as new distant metastases mostly in skeletal locations was high in this group compared to euthyroid group (p = 0.027; OR 4.121, CI 1.008-15.600). There was higher incidence of cumulative metastatic diseases in papillary thyroid cancer associated with Graves' disease.

Conclusion: Papillary thyroid cancers associated with Graves' disease show aggressive biological behaviour and favoured site of distant metastases was osseous locations. Early diagnosis by routine screening of Graves' disease patients with ultrasound imaging and aspiration studies is recommended.

与巴塞杜氏病相关的甲状腺乳头状癌的预后:病例对照研究
导言目前,甲状腺切除术已不再是巴塞杜氏病的常用治疗方法。关于甲状腺结节的发病率以及伴随巴塞杜氏病的甲状腺结节的癌症风险还存在争议。研究设计:研究设计:对与巴塞杜氏病相关的甲状腺乳头状癌和甲状腺功能正常者进行回顾性病例对照研究。比较两组甲状腺乳头状癌的病理特征和预后:结果:两组患者的肿瘤特征无明显差异。对患者的平均随访时间为77.32个月,结果发现,伴有巴塞杜氏病的甲状腺乳头状癌患者的疾病进展发生率很高(P = 0.034;OR 2.747,CI 1.078-7.004)。与甲状腺功能正常组相比,该组患者的疾病进展主要表现为骨骼部位的新发远处转移(p = 0.027;OR 4.121,CI 1.008-15.600)。结论:与巴塞杜氏病相关的甲状腺乳头状癌的累积转移性疾病发生率较高:结论:与巴塞杜氏病相关的甲状腺乳头状癌表现出侵袭性生物学行为,远处转移的首选部位是骨质部位。建议对巴塞杜氏病患者进行常规筛查,通过超声波成像和抽吸检查进行早期诊断。
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来源期刊
Journal of Thyroid Research
Journal of Thyroid Research ENDOCRINOLOGY & METABOLISM-
CiteScore
4.40
自引率
0.00%
发文量
10
审稿时长
17 weeks
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