Comparison of Vitamin D Serum Values between Rheumatoid Arthritis and Lupus Populations: An Observational Study.

Q4 Medicine

Open Rheumatology Journal Pub Date : 2018-04-30 eCollection Date: 2018-01-01 DOI:10.2174/1874312901812010065

Sahebari Maryam, Elham Atabati, Ravanshad Yalda

{"title":"Comparison of Vitamin D Serum Values between Rheumatoid Arthritis and Lupus Populations: An Observational Study.","authors":"Sahebari Maryam, Elham Atabati, Ravanshad Yalda","doi":"10.2174/1874312901812010065","DOIUrl":null,"url":null,"abstract":"Background: In recent years, the role of Vitamin D (VitD), as an immunomedulator in autoimmune diseases, has been evaluated in basic science and practice. There is a considerable volume of data on the effect of VitD position in lupus and rheumatoid arthritis exacerbation.Objective: This study aims to compare VitD serum values in lupus (SLE) and Rheumatoid Arthritis (RA) in the geographical region of northeastern Iran.Methods: Lupus and RA Patients were selected with various disease activity levels. All the patients received an equal amount of VitD supplementation and were selected by the same inclusion and exclusion criteria. VitD serum values were measured by a commercial ELISA kit. Data were analyzed in SPSS-15.Results: A total of 148 SLE and 156 RA patients were studied. VitD serum levels were 66.54±41.2 nmol/l in the SLE group and 83.74±46.45 nmol/l in the RA group. Statistical analysis showed that VitD serum levels were lower in lupus patients than RA ones (p=0.006).Conclusion: VitD serum values were lower in lupus patients than RA ones. Since VitD deficiency is very common in Iran, physiologic doses of VitD supplementation in patients lead to higher serum levels of VitD. Lower VitD values in lupus patients compared with RA ones may stem from intestinal malabsorption, higher doses of corticosteroid therapy, renal involvement and proteinuria, different polymorphisms of VitD receptors, and more sun protection strategies in lupus patients.","PeriodicalId":39124,"journal":{"name":"Open Rheumatology Journal","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2018-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944124/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Open Rheumatology Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1874312901812010065","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2018/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Background: In recent years, the role of Vitamin D (VitD), as an immunomedulator in autoimmune diseases, has been evaluated in basic science and practice. There is a considerable volume of data on the effect of VitD position in lupus and rheumatoid arthritis exacerbation.

Objective: This study aims to compare VitD serum values in lupus (SLE) and Rheumatoid Arthritis (RA) in the geographical region of northeastern Iran.

Methods: Lupus and RA Patients were selected with various disease activity levels. All the patients received an equal amount of VitD supplementation and were selected by the same inclusion and exclusion criteria. VitD serum values were measured by a commercial ELISA kit. Data were analyzed in SPSS-15.

Results: A total of 148 SLE and 156 RA patients were studied. VitD serum levels were 66.54±41.2 nmol/l in the SLE group and 83.74±46.45 nmol/l in the RA group. Statistical analysis showed that VitD serum levels were lower in lupus patients than RA ones (p=0.006).

Conclusion: VitD serum values were lower in lupus patients than RA ones. Since VitD deficiency is very common in Iran, physiologic doses of VitD supplementation in patients lead to higher serum levels of VitD. Lower VitD values in lupus patients compared with RA ones may stem from intestinal malabsorption, higher doses of corticosteroid therapy, renal involvement and proteinuria, different polymorphisms of VitD receptors, and more sun protection strategies in lupus patients.

查看原文本刊更多论文

类风湿关节炎和狼疮人群维生素D血清值的比较:一项观察性研究。

背景:近年来，维生素D (VitD)作为一种免疫调节剂在自身免疫性疾病中的作用在基础科学和实践中得到了评价。关于VitD位置在狼疮和类风湿关节炎恶化中的影响有相当大的数据量。目的:本研究旨在比较伊朗东北部地区狼疮(SLE)和类风湿关节炎(RA)患者血清VitD值。方法:选择不同疾病活动度的狼疮、RA患者。所有患者均接受等量的维生素d补充，并按照相同的纳入和排除标准进行选择。用商用ELISA试剂盒测定血清VitD值。数据用SPSS-15进行分析。结果:共研究SLE患者148例，RA患者156例。SLE组血清VitD水平为66.54±41.2 nmol/l, RA组为83.74±46.45 nmol/l。统计分析显示狼疮患者血清VitD水平低于类风湿关节炎患者(p=0.006)。结论:狼疮患者血清VitD值低于RA患者。由于维生素d缺乏症在伊朗非常普遍，患者生理剂量补充维生素d会导致血清维生素d水平升高。与类风湿性关节炎患者相比，狼疮患者维生素d值较低可能与肠道吸收不良、高剂量皮质类固醇治疗、肾脏受累和蛋白尿、维生素d受体的不同多态性以及狼疮患者更多的防晒策略有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Open Rheumatology Journal Medicine-Rheumatology

CiteScore

0.80

自引率

0.00%

发文量

期刊介绍： ENTHAM Open publishes a number of peer-reviewed, open access journals. These free-to-view online journals cover all major disciplines of science, medicine, technology and social sciences. BENTHAM Open provides researchers a platform to rapidly publish their research in a good-quality peer-reviewed journal. All peer-reviewed accepted submissions meeting high research and ethical standards are published with free access to all.