Significance of Testing Anti-Thyroid Autoantibodies in Patients with Deranged Thyroid Profile.

IF 1.7 Q4 ENDOCRINOLOGY & METABOLISM
Journal of Thyroid Research Pub Date : 2018-04-11 eCollection Date: 2018-01-01 DOI:10.1155/2018/9610497
Hamid Nawaz Tipu, Dawood Ahmed, Muhammad Mukarram Bashir, Naveed Asif
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引用次数: 19

Abstract

Background: We hypothesized that anti-thyroid antibodies are more often positive in individuals with deranged thyroid profile.

Methods: This prospective cohort was done in Immunology Department, Armed Forces Institute of Pathology, Rawalpindi, Pakistan, from Jan 2017 to Oct 2017. All the samples that were referred to us for testing anti-thyroid antibodies (anti-TPO or anti-TG antibodies) and thyroid profile were included in the study. There were no exclusion criteria. Tests for anti-thyroid antibodies were performed by ELISA and thyroid profile by chemiluminescence. SPSS 23.0 was used for statistical analysis.

Results: Over a course of a ten-month study period, we received a total of 316 serum samples for anti-TPO/TG antibodies along with thyroid profile testing (TSH). These included 115 males (36.4%) and 201 females (63.6%). Their age ranged from 3 to 89 years (mean ± SD, 42.22 ± 18.09). Anti-TPO antibodies were more often positive when TSH was deranged (p value 0.001). Anti-TPO antibodies are more often raised in females, in terms of both prevalence (p 0.001) and mean rank (p 0.002).

Conclusion: As anti-thyroid antibodies are more often present when TSH is deranged, such individuals should be screened for anti-thyroid antibodies. This importance of screening is compounded by the fact that anti-thyroid antibodies may be positive in a significant percentage of elderly people.

甲状腺功能紊乱患者检测抗甲状腺自身抗体的意义。
背景:我们假设抗甲状腺抗体在甲状腺功能紊乱的个体中更常呈阳性。方法:该前瞻性队列研究于2017年1月至2017年10月在巴基斯坦拉瓦尔品第武装部队病理研究所免疫学科进行。所有提交给我们检测抗甲状腺抗体(抗tpo或抗tg抗体)和甲状腺特征的样本都被纳入研究。没有排除标准。ELISA法检测抗甲状腺抗体,化学发光法检测甲状腺谱。采用SPSS 23.0进行统计分析。结果:在为期10个月的研究期间,我们共收到316份血清样本,用于抗tpo /TG抗体以及甲状腺特征测试(TSH)。其中男性115人(36.4%),女性201人(63.6%)。年龄3 ~ 89岁(mean±SD, 42.22±18.09)。当TSH紊乱时,抗tpo抗体更常呈阳性(p值0.001)。从患病率(p 0.001)和平均等级(p 0.002)来看,抗tpo抗体在女性中更常升高。结论:当TSH异常时,抗甲状腺抗体更常出现,这类个体应进行抗甲状腺抗体筛查。由于抗甲状腺抗体在很大比例的老年人中可能呈阳性,因此筛查的重要性更加突出。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Thyroid Research
Journal of Thyroid Research ENDOCRINOLOGY & METABOLISM-
CiteScore
4.40
自引率
0.00%
发文量
10
审稿时长
17 weeks
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