Diagnostic Accuracy of Preoperative Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Detecting Occult Papillary Thyroid Microcarcinomas in Benign Multinodular Goitres.

IF 1.7 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Thyroid Research Pub Date : 2018-04-23 eCollection Date: 2018-01-01 DOI:10.1155/2018/3470429

Dimitrios K Manatakis, Sophia Tseleni-Balafouta, Lazaros Tzelves, Dimitrios Balalis, Adelais Tzortzopoulou, Dimitrios P Korkolis, George H Sakorafas, Emmanouil Gontikakis, Georgios Plataniotis

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引用次数: 7

Abstract

Objective: To investigate the diagnostic accuracy of neutrophil-to-lymphocyte (NLR) and platelet-to-lymphocyte (PLR) ratios in detecting occult papillary thyroid microcarcinomas in benign, multinodular goitres.

Methods: 397 total thyroidectomy patients were identified from the institutional thyroid surgery database between 2007 and 2016 (94 males, 303 females, mean age 53 ± 14.5 years). NLR and PLR were calculated as the absolute neutrophil and absolute platelet counts divided by the absolute lymphocyte count, respectively, based on the preoperative complete blood cell count.

Results: NLR was significantly higher in carcinomas and microcarcinomas compared to benign pathology (p = 0.026), whereas a direct association could not be established for PLR. Both NLR and PLR scored low in all parameters of diagnostic accuracy, with overall accuracy ranging between 45 and 50%.

Conclusions: As surrogate indices of the systemic inflammatory response, NLR and PLR are inexpensive and universally available from routine blood tests. Although we found higher NLR values in cases of malignancy, NLR and PLR cannot effectively predict the presence of occult papillary microcarcinomas in otherwise benign, multinodular goitres.

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中性粒细胞/淋巴细胞及血小板/淋巴细胞比值在良性多结节甲状腺隐匿性乳头状微癌诊断中的准确性。

目的:探讨中性粒细胞与淋巴细胞比值(NLR)和血小板与淋巴细胞比值(PLR)对良性多结节甲状腺隐匿性乳头状微癌的诊断准确性。方法:从2007 - 2016年机构甲状腺手术数据库中筛选397例甲状腺全切除术患者(男性94例，女性303例，平均年龄53±14.5岁)。NLR和PLR分别以术前全血细胞计数为基础，用中性粒细胞绝对计数和血小板绝对计数除以淋巴细胞绝对计数计算。结果:与良性病理相比，癌和微癌的NLR明显高于良性病理(p = 0.026)，而与PLR没有直接联系。NLR和PLR在诊断准确性的所有参数中得分都很低，总体准确率在45%到50%之间。结论:NLR和PLR作为全身性炎症反应的替代指标，价格低廉，可从常规血液检查中普遍获得。虽然我们发现恶性肿瘤的NLR值较高，但NLR和PLR不能有效预测良性多结节甲状腺中是否存在隐匿乳头状微癌。

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