The ups and downs of S. aureus nasal carriage.

IF 0.8 4区 数学 Q4 BIOLOGY
Angela M Jarrett, Nicholas G Cogan
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引用次数: 4

Abstract

Staphylococcus aureus infections are a growing concern worldwide due to the increasing number of strains that exhibit antibiotic resistance. Recent studies have indicated that some percentage of people carry the bacteria in the nasal cavity and therefore are at a higher risk of subsequent, and more serious, infections in other parts of the body. However, individuals carrying the infection can be classified as only intermittent carriers versus persistent carriers, being able to eliminate the bacteria and later colonized again. Using a model of bacterial colonization of the anterior nares, we investigate oscillatory patterns related to intermittent carriage of S. aureus. Following several studies using global sensitivity analysis techniques, various insights into the model's behaviour were made including interacting effects of the bacteria's growth rate and movement in the mucus, suggesting parameter connections associated with biofilm-like behaviour. Here the bacterial growth rate and bacterial movement are explicitly connected, leading to expanded oscillatory behaviour in the model. We suggest possible implications that this oscillatory behaviour can have on the definition of intermittent carriage and discuss differences in the bacterial virulence dependent upon individual host health. Furthermore, we show that connecting the bacterial growth and movement also expands the region of the parameter space for which the bacteria are able to survive and persist.

金黄色葡萄球菌鼻腔运载的起伏。
金黄色葡萄球菌感染日益受到全世界的关注,因为越来越多的菌株表现出抗生素耐药性。最近的研究表明,一定比例的人鼻腔中携带这种细菌,因此在身体其他部位感染这种细菌的风险更高,也更严重。然而,携带感染的个体可以分为间歇性携带者和持久性携带者,后者能够消灭细菌并随后再次定植。使用细菌定植的前鼻模型,我们研究振荡模式相关的间歇携带金黄色葡萄球菌。在使用全局敏感性分析技术进行了几项研究之后,对模型的行为进行了各种见解,包括细菌生长速度和粘液运动的相互作用,表明与生物膜样行为相关的参数联系。在这里,细菌的生长速度和细菌的运动被明确地联系在一起,导致了模型中扩展的振荡行为。我们提出了这种振荡行为可能对间歇性携带的定义产生的影响,并讨论了依赖于个体宿主健康的细菌毒力的差异。此外,我们表明,连接细菌的生长和运动也扩大了细菌能够生存和持续的参数空间区域。
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来源期刊
CiteScore
2.20
自引率
0.00%
发文量
15
审稿时长
>12 weeks
期刊介绍: Formerly the IMA Journal of Mathematics Applied in Medicine and Biology. Mathematical Medicine and Biology publishes original articles with a significant mathematical content addressing topics in medicine and biology. Papers exploiting modern developments in applied mathematics are particularly welcome. The biomedical relevance of mathematical models should be demonstrated clearly and validation by comparison against experiment is strongly encouraged. The journal welcomes contributions relevant to any area of the life sciences including: -biomechanics- biophysics- cell biology- developmental biology- ecology and the environment- epidemiology- immunology- infectious diseases- neuroscience- pharmacology- physiology- population biology
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