[Research progress in pneumolysin].

微生物学报 Pub Date : 2017-03-04

Wu Rui, Kui Nie, Rendong Fang

引用次数: 0

Abstract

Pneumolysin is a multifunctional virulence factor expressed by Streptococcus pneumoniae. Pneumolysin includes 4 domains and is a member of cholesterol-dependent cytolysins. Pneumolysin has extensive cytotoxicity to a range of host cells. Furthermore, pneumolysin can activate complement classical pathway, and induce macrophages and monocytes to produce proinflammatory cytokines, mediate host immune responses. Consequently, pneumolysin is a potential candidate target for research and development of vaccines and drugs. In this review, the latest research progresses on the structure and function of pneumolysin, and related vaccines are discussed.

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[溶血素研究进展]。

溶肺素是一种由肺炎链球菌表达的多功能毒力因子。溶肺素包括4个结构域，是胆固醇依赖性细胞溶血素的一员。溶肺素对多种宿主细胞具有广泛的细胞毒性。此外，溶气素可以激活补体经典途径，诱导巨噬细胞和单核细胞产生促炎细胞因子，介导宿主免疫反应。因此，溶肺素是研究和开发疫苗和药物的潜在候选靶点。本文就溶血素的结构、功能及相关疫苗的最新研究进展作一综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

微生物学报

自引率

0.00%

发文量

7960

期刊介绍： Acta Microbiologica Sinica(AMS) is a peer-reviewed monthly (one volume per year)international journal,founded in 1953.It covers a wide range of topics in the areas of general and applied microbiology.The journal publishes original papers,reviews in microbiological science,and short communications describing unusual observations. Acta Microbiologica Sinica has been indexed in Index Copernicus (IC),Chemical Abstract (CA),Excerpt Medica Database (EMBASE),AJ of Viniti (Russia),Biological Abstracts (BA),Chinese Science Citation Database (CSCD),China National Knowledge Infrastructure(CNKI),Institute of Scientific and Technical Information of China(ISTIC),Chinese Journal Citation Report(CJCR),Chinese Biological Abstracts,Chinese Pharmaceutical Abstracts,Chinese Medical Abstracts and Chinese Science Abstracts.