{"title":"[Advances in Zika vaccines].","authors":"Ran Wang, Hui Chen, Jing An","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Aedes (a genus of mosquitoes) transfers Zika virus (ZIKV) to humans. About two billion people worldwide live in ZIKV-affected areas. The outbreak of ZIKV in Central and South America threats public health worldwide, especially for pregnant women and their fetuses. ZIKV infection has become one of the major causes of neonatal congenital microcephaly and adult Guillain-Barre syndrome. No effective vaccine and treatment are available now against ZIKV infection. The first Zika vaccine is a DNA vaccine which affords complete protection against ZIKV and induces a high level of specific antibody titers. Advantages of DNA vaccines are simple to design and produce, safe for adults and fetuses, and without virulence recovery induced by reproducible vaccines. Some positive vaccines including traditional and emerging ones are in research and some progresses have been achieved. This article reviews the current situation and progress of Zika vaccines.</p>","PeriodicalId":7120,"journal":{"name":"微生物学报","volume":"57 2","pages":"188-96"},"PeriodicalIF":0.0000,"publicationDate":"2017-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"微生物学报","FirstCategoryId":"1089","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Aedes (a genus of mosquitoes) transfers Zika virus (ZIKV) to humans. About two billion people worldwide live in ZIKV-affected areas. The outbreak of ZIKV in Central and South America threats public health worldwide, especially for pregnant women and their fetuses. ZIKV infection has become one of the major causes of neonatal congenital microcephaly and adult Guillain-Barre syndrome. No effective vaccine and treatment are available now against ZIKV infection. The first Zika vaccine is a DNA vaccine which affords complete protection against ZIKV and induces a high level of specific antibody titers. Advantages of DNA vaccines are simple to design and produce, safe for adults and fetuses, and without virulence recovery induced by reproducible vaccines. Some positive vaccines including traditional and emerging ones are in research and some progresses have been achieved. This article reviews the current situation and progress of Zika vaccines.
期刊介绍：
Acta Microbiologica Sinica(AMS) is a peer-reviewed monthly (one volume per year)international journal,founded in 1953.It covers a wide range of topics in the areas of general and applied microbiology.The journal
publishes original papers,reviews in microbiological science,and short communications describing unusual observations.
Acta Microbiologica Sinica has been indexed in Index Copernicus (IC),Chemical Abstract (CA),Excerpt Medica Database (EMBASE),AJ of Viniti (Russia),Biological Abstracts (BA),Chinese Science Citation Database
(CSCD),China National Knowledge Infrastructure(CNKI),Institute of Scientific and Technical Information of China(ISTIC),Chinese Journal Citation Report(CJCR),Chinese Biological Abstracts,Chinese Pharmaceutical
Abstracts,Chinese Medical Abstracts and Chinese Science Abstracts.
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