A Double Blind, Randomized Cross-Over Trial of Tyrosine Treatment on Cognitive Function and Psychological Parameters in Severe Hospitalized Anorexia Nervosa Patients.

Israel journal of psychiatry Pub Date : 2017-01-01

Mor Israely, Anca Ram, Rachel Brandeis, Zvia Alter, Yosefa Avraham, Elliot M Berry

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Abstract

Background: Anorexia nervosa (AN) is characterized by self-induced malnutrition, affecting body image, mood, cognition and survival. Tyrosine, an essential amino acid is the precursor of catecholamines. The use of tyrosine to treat AN is based on experiments on diet restricted mice, in which it increased food consumption, improved cognitive function and elevated brain catecholamines. We evaluated the effect of oral tyrosine administration on the cognition and emotional state of patients with AN. We hypothesized that tyrosine may improve cognitive function without changing body weight, thus "kick-start" nutritional rehabilitation.

Methods: 19 female hospitalized patients with chronic AN were supplemented with L-tyrosine (100 mg/kg/day)/ placebo capsules for a three-week period in a double blind, randomized, cross-over study. Participants were evaluated cognitively and psychologically.

Results: Tyrosine shortened reaction time and test duration in memory tasks and improved depressive mood. No side effects were noted with the use of tyrosine.

Conclusions: Tyrosine may improve cognitive function and psychological traits associated with AN.

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酪氨酸治疗对重度神经性厌食症住院患者认知功能和心理参数的双盲、随机交叉试验

背景:神经性厌食症(Anorexia nervosa, AN)以自身营养不良为特征，影响身体形象、情绪、认知和生存。酪氨酸是一种必需氨基酸，是儿茶酚胺的前体。使用酪氨酸治疗AN是基于对饮食限制小鼠的实验，在实验中，酪氨酸增加了食物消耗，改善了认知功能，提高了脑儿茶酚胺。我们评估了口服酪氨酸对AN患者认知和情绪状态的影响。我们假设酪氨酸可以在不改变体重的情况下改善认知功能，从而“启动”营养康复。方法:在一项双盲、随机、交叉研究中，对19例慢性AN住院女性患者补充l -酪氨酸(100 mg/kg/天)/安慰剂胶囊，为期3周。研究人员对参与者进行了认知和心理评估。结果:酪氨酸缩短了记忆任务的反应时间和测试时间，改善了抑郁情绪。使用酪氨酸没有发现副作用。结论:酪氨酸可改善AN患者的认知功能和心理特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Israel journal of psychiatry

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