The Effect of Tranexamic Acid on Preventing Post-partum Hemorrhage Due to Uterine Atony: A Triple-blind Randomized Clinical Trial.

IF 3.2 Q2 Pharmacology, Toxicology and Pharmaceutics

Current clinical pharmacology Pub Date : 2018-01-01 DOI:10.2174/1574884713666180507101002

Mahvash Zargar, Roshan Nikbakht, Mahzad Ahmadi

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引用次数: 7

Abstract

Background: Postpartum haemorrhage (PPH) is an important cause of early maternal death which needs to be controlled.

Objective: This study was designed to compare the effect of intravenous tranexamic acid (TXA) and prostaglandin analogue on reducing PPH resulted from uterine atony in women undergoing C section or vaginal delivery.

Method: A randomized, triple-blind, placebo-controlled study was conducted on 248 pregnant women with PPH due to uterine atony who were randomly assigned into two groups of TXA as the intervention group (n=124) and prostaglandin analogue as the control group (n=124). The intervention group received 4 g TXA for an hour and then 1 g over 6 hours infusion intravenously and the control group received prostaglandin analogue.

Results: Postoperative bleeding did not significantly differ between the two groups (68.2±6.1 ml and 69.1±175.73 ml, respectively, P =0.6). Moreover, hemoglobin declines were 1±0.4 g/dl and 1.2±0.5 g/dL in TXA and prostaglandin group respectively, indicating that the difference was not statistically significant (P =0.7).

Conclusion: The results of the present study showed that administrating intravenous TXA had comparable effects with prostaglandin analogue on reducing PPH in women with uterine atony and in those undergoing C section or vaginal delivery. Therefore, TXA can be used instead of prostaglandin in managing such patients.

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氨甲环酸预防子宫张力所致产后出血的三盲随机临床试验

背景:产后出血(PPH)是导致产妇早期死亡的重要原因，需要加以控制。目的:比较静脉注射氨甲环酸(TXA)和前列腺素类似物对降低剖腹产和阴道分娩妇女子宫张力所致PPH的影响。方法:采用随机、三盲、安慰剂对照的方法，将248例因子宫张力不全而发生PPH的孕妇随机分为两组:TXA为干预组(n=124)，前列腺素类似物为对照组(n=124)。干预组给予TXA 4 g，连续1 h静脉滴注，6 h静脉滴注，对照组给予前列腺素类似物。结果:两组患者术后出血无显著差异(分别为68.2±6.1 ml和69.1±175.73 ml, P =0.6)。TXA组和前列腺素组血红蛋白下降幅度分别为1±0.4 g/dl和1.2±0.5 g/dl，差异无统计学意义(P =0.7)。结论:本研究结果表明，静脉注射TXA与前列腺素类似物在降低子宫张力妇女和剖腹产或阴道分娩妇女PPH方面具有相当的效果。因此，TXA可以代替前列腺素治疗此类患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current clinical pharmacology PHARMACOLOGY & PHARMACY-

CiteScore

3.60

自引率

0.00%

发文量

期刊介绍： Current Clinical Pharmacology publishes frontier reviews on all the latest advances in clinical pharmacology. The journal"s aim is to publish the highest quality review articles in the field. Topics covered include: pharmacokinetics; therapeutic trials; adverse drug reactions; drug interactions; drug metabolism; pharmacoepidemiology; and drug development. The journal is essential reading for all researchers in clinical pharmacology.