The Study of White Matter Hyperintensity (WMH) and Factors Related to Geriatric Late-Onset Depression.

上海精神医学 Pub Date : 2018-02-25 DOI:10.11919/j.issn.1002-0829.217038

Jinghua Wang, Wei Li, Ling Yue, Bo Hong, Na An, Guanjun Li, Shifu Xiao

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引用次数: 6

Abstract

Background: Geriatric depression is one of the most common and harmful mental illnesses seen in the elderly. However, there are few studies focusing on the relationship between late-onset depression (LOD) and social and psychological factors, as well as brain structure.

Aims: To explore factors related to late-onset depression (LOD) in elderly patients.

Methods: 24 first onset LOD patients over 60 years old (meeting ICD-10 diagnostic criteria for depression) and 23 non-depressed elders were selected for inclusion into this study. Scale assessments, including Fazelasscale for white matter hyperintensity (WMH) high signal level and the MTA-scale for medial temporal lobe atrophy levels, were combined with general demography and sociology data to find factors related to LOD.

Results: There was no significant difference in age (t=0.419, p=0.678), gender (X²=1.705, p=0.244), or years of education (t=1.478, p=0.146) between the two groups. However, statistical differences were shown on scores on the WMH, (X²=7.817, p=0.008), periventricular white matter hyperintensity (PWMH)(Fisher exact test: p=0.031), having or not having religious beliefs (Fisher exact test: p=0.265) and family harmony (yes or no) (Fisher exact test: p=0.253) between the LOD group and control group. The results of linear regression analysis showed that the total score for WMH, religious beliefs (with or without) and family harmony (yes or no) were associated with depressive symptomology.

Conclusion: Scores on the WMH, religious beliefs and family harmony are all potentially related to LOD in elderly patients.

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老年迟发性抑郁症白质高强度(WMH)及其相关因素研究。

背景:老年抑郁症是老年人最常见和最有害的精神疾病之一。然而，关于迟发性抑郁与社会心理因素以及大脑结构之间关系的研究却很少。目的:探讨老年迟发性抑郁(LOD)的相关因素。方法:选取24例60岁以上(符合ICD-10抑郁症诊断标准)的首发LOD患者和23例无抑郁症的老年人作为研究对象。量表评估，包括白质高强度(WMH)高信号水平的Fazelasscale量表和内侧颞叶萎缩水平的mta量表，与一般人口学和社会学数据相结合，以寻找与LOD相关的因素。结果:两组患者年龄(t=0.419, p=0.678)、性别(X2=1.705, p=0.244)、受教育年限(t=1.478, p=0.146)差异均无统计学意义。然而，在WMH (X2=7.817, p=0.008)、心室周围白质高强度(PWMH)(Fisher精确检验:p=0.031)、是否有宗教信仰(Fisher精确检验:p=0.265)和家庭和谐(是或否)(Fisher精确检验:p=0.253)得分上，LOD组与对照组之间存在统计学差异。线性回归分析结果显示，WMH总分、宗教信仰(有或没有)和家庭和谐(有或没有)与抑郁症状相关。结论:WMH、宗教信仰、家庭和谐得分均与老年患者LOD存在潜在关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

上海精神医学

自引率

0.00%

发文量

2341

期刊介绍： Shanghai archives of psychiatry (bimonthly) was founded in 1959 and is sponsored by Shanghai Mental Health Center. The journal is aimed at mental health workers across the country, including psychiatrists and nurses, clinical psychologists, social workers, and people who are committed to the cause of mental health. It focuses on reporting clinical research results and practical experience in the field of psychiatry, and introduces the latest knowledge in psychiatry and related fields. The columns include monographs, case reports, clinical case discussions, reviews, mental health and law, and debates and discussions.