Synthesis of novel ligands targeting phenazine biosynthesis proteins as a strategy for antibiotic intervention.

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Monatshefte Fur Chemie Pub Date : 2018-01-01 Epub Date: 2017-11-30 DOI:10.1007/s00706-017-2100-z

Nikolaus Guttenberger, Thomas Schlatzer, Mario Leypold, Sebastian Tassoti, Rolf Breinbauer

引用次数: 6

Abstract

Abstract: In this contribution, we report synthetic strategies towards potential ligands for the study of binding differences between PhzE, the first enzyme in the biosynthesis of phenazines, and the related enzyme anthranilate synthase. The ligands were designed with the overriding goal to develop new antibiotics via downregulation of phenazine biosynthesis.

Graphical abstract:

Abstract Image

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针对非那嗪生物合成蛋白的新型配体的合成作为抗生素干预策略。

摘要:在这篇文章中，我们报道了潜在配体的合成策略，以研究phenazines生物合成的第一个酶PhzE与相关酶anthanilate synthase之间的结合差异。设计配体的首要目标是通过下调非那嗪的生物合成来开发新的抗生素。图形化的简介:

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Monatshefte Fur Chemie 化学-化学综合

CiteScore

3.70

自引率

5.60%

发文量

116

审稿时长

3.3 months

期刊介绍： "Monatshefte für Chemie/Chemical Monthly" was originally conceived as an Austrian journal of chemistry. It has evolved into an international journal covering all branches of chemistry. Featuring the most recent advances in research in analytical chemistry, biochemistry, inorganic, medicinal, organic, physical, structural, and theoretical chemistry, Chemical Monthly publishes refereed original papers and a section entitled "Short Communications". Reviews, symposia in print, and issues devoted to special fields will also be considered.