Assessment of Anti-TB Drug Nonadherence and Associated Factors among TB Patients Attending TB Clinics in Arba Minch Governmental Health Institutions, Southern Ethiopia.

Tuberculosis Research and Treatment Pub Date : 2018-02-18 eCollection Date: 2018-01-01 DOI:10.1155/2018/3705812

Addisu Alemayehu Gube, Megbaru Debalkie, Kalid Seid, Kiberalem Bisete, Asfaw Mengesha, Abubeker Zeynu, Freselam Shimelis, Feleke Gebremeskel

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引用次数: 36

Abstract

Background: Tuberculosis (TB) is an infectious disease caused by the bacillus Mycobacterium tuberculosis. Nonadherence to anti-TB treatment may result in the emergence of multidrug-resistant TB, prolonged infectiousness, and poor tuberculosis treatment outcomes. Ethiopia is one of the seven countries that reported lower rates of treatment success (84%). This study assessed anti-TB drug nonadherence and associated factors among TB patients in Arba Minch governmental health institutions.

Methods: An institution based cross-sectional study design was conducted from April 15 to May 30, 2017. A systematic sampling technique was employed to select the study subjects. Data was collected using a semistructured questionnaire with Morisky Medication Adherence Scale-8 (MMAS-8) and was entered, cleaned, and analyzed in SPSS version 20.

Results: The study included 271 TB patients with a response rate of 96.4%; 58.3% were males and 64.9% were Gamo by ethnicity. The overall nonadherence was 67 (24.7%) (CI = 20.0-30.4). Nonadherence was high if the patients experienced side effects (AOR = 13.332; 95% CI = 2.282-77.905), were far from the health facility (AOR = 21.830; 95% CI = 0.054-77.500), and experienced prolonged waiting time to get medical services (AOR = 14.260; 95% CI = 2.135-95.241).

Conclusions: The proportion of TB patients that did not adhere to anti-TB drugs was high in Arba Minch governmental health institutions.

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埃塞俄比亚南部Arba Minch政府卫生机构结核病门诊结核病患者抗结核药物依从性及相关因素评估

背景:结核病是一种由结核分枝杆菌引起的传染病。不坚持抗结核治疗可能导致出现耐多药结核病、延长传染性和结核病治疗效果差。埃塞俄比亚是报告治疗成功率较低(84%)的七个国家之一。本研究评估了Arba Minch政府卫生机构中结核病患者抗结核药物不依从及其相关因素。方法:2017年4月15日至5月30日采用基于机构的横断面研究设计。采用系统抽样技术选择研究对象。采用Morisky药物依从性量表-8 (MMAS-8)的半结构化问卷收集数据，并在SPSS version 20中进行输入、清理和分析。结果:纳入271例TB患者，有效率为96.4%;男性占58.3%，加莫族占64.9%。总体不依从为67例(24.7%)(CI = 20.0-30.4)。出现不良反应的患者不依从性较高(AOR = 13.332;95% CI = 2.282-77.905)，远离医疗机构(AOR = 21.830;95% CI = 0.054-77.500)，且就诊等待时间较长(AOR = 14.260;95% ci = 2.135-95.241)。结论:阿尔巴明省政府卫生机构结核病患者未坚持使用抗结核药物的比例较高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Tuberculosis Research and Treatment

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17 weeks