{"title":"The Benefit of Prescribing Vitamin D as Add on Therapy on the Electrocardiographic Changes in Epileptic Patients.","authors":"Marwan S Al-Nimer","doi":"10.2174/1574884713666180412151139","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Epileptic children and adolescent have a significantly low serum level of vitamin D due to the effect of antiepileptic drugs on the vitamin D metabolism. Those patients are at risk of cardiovascular events.</p><p><strong>Objective: </strong>This study aimed to show that epileptic patients who treated with antiepileptic drugs supplemented with vitamin D are free from the electrocardiograph changes compared with those treated with antiepileptic drugs.</p><p><strong>Method: </strong>This cross-sectional study included, 121 epileptic patients aged < 18 years of both genders with a history of idiopathic generalized tonic clonic seizure. They grouped into Group I (n=20) patients without medical treatment, Group II (n=76) patients treated with antiepileptic drugs, and vitamin D Group III (n=25) patients treated with antiepileptic drugs supplemented with vitamin D3 vitamin D. Each participant subjected to the electrocardiogram investigation at the time of entry into the study.</p><p><strong>Results: </strong>Group III patients had a significant decrease of QRS complex, QRS dispersion QTcorrected, and TQ duration compared with Group II. Group I patients, had a significant increase of QRS complex duration, compared with Group II patients. Four patients of Group II showed a significant prolonged QT-interval in the QT nomogram. Three patients had a JT index (an indicator of ventricular hyperpolarization) more than the normal cutoff level of 112. The area under the curve of receiving operating characteristics showed significant favorable effects of vitamin D supplementation on the different variables of electrocardiograph.</p><p><strong>Conclusion: </strong>Vitamin D supplementation may correct the changes in the electrocardiograph observed in idiopathic generalized tonic clonic seizure treated with antiepileptic medicines, and our observations warrant larger studies.</p>","PeriodicalId":10746,"journal":{"name":"Current clinical pharmacology","volume":null,"pages":null},"PeriodicalIF":3.2000,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current clinical pharmacology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1574884713666180412151139","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
引用次数: 1
Abstract
Background: Epileptic children and adolescent have a significantly low serum level of vitamin D due to the effect of antiepileptic drugs on the vitamin D metabolism. Those patients are at risk of cardiovascular events.
Objective: This study aimed to show that epileptic patients who treated with antiepileptic drugs supplemented with vitamin D are free from the electrocardiograph changes compared with those treated with antiepileptic drugs.
Method: This cross-sectional study included, 121 epileptic patients aged < 18 years of both genders with a history of idiopathic generalized tonic clonic seizure. They grouped into Group I (n=20) patients without medical treatment, Group II (n=76) patients treated with antiepileptic drugs, and vitamin D Group III (n=25) patients treated with antiepileptic drugs supplemented with vitamin D3 vitamin D. Each participant subjected to the electrocardiogram investigation at the time of entry into the study.
Results: Group III patients had a significant decrease of QRS complex, QRS dispersion QTcorrected, and TQ duration compared with Group II. Group I patients, had a significant increase of QRS complex duration, compared with Group II patients. Four patients of Group II showed a significant prolonged QT-interval in the QT nomogram. Three patients had a JT index (an indicator of ventricular hyperpolarization) more than the normal cutoff level of 112. The area under the curve of receiving operating characteristics showed significant favorable effects of vitamin D supplementation on the different variables of electrocardiograph.
Conclusion: Vitamin D supplementation may correct the changes in the electrocardiograph observed in idiopathic generalized tonic clonic seizure treated with antiepileptic medicines, and our observations warrant larger studies.
期刊介绍:
Current Clinical Pharmacology publishes frontier reviews on all the latest advances in clinical pharmacology. The journal"s aim is to publish the highest quality review articles in the field. Topics covered include: pharmacokinetics; therapeutic trials; adverse drug reactions; drug interactions; drug metabolism; pharmacoepidemiology; and drug development. The journal is essential reading for all researchers in clinical pharmacology.