The Benefit of Prescribing Vitamin D as Add on Therapy on the Electrocardiographic Changes in Epileptic Patients.

IF 3.2 Q2 Pharmacology, Toxicology and Pharmaceutics
Marwan S Al-Nimer
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引用次数: 1

Abstract

Background: Epileptic children and adolescent have a significantly low serum level of vitamin D due to the effect of antiepileptic drugs on the vitamin D metabolism. Those patients are at risk of cardiovascular events.

Objective: This study aimed to show that epileptic patients who treated with antiepileptic drugs supplemented with vitamin D are free from the electrocardiograph changes compared with those treated with antiepileptic drugs.

Method: This cross-sectional study included, 121 epileptic patients aged < 18 years of both genders with a history of idiopathic generalized tonic clonic seizure. They grouped into Group I (n=20) patients without medical treatment, Group II (n=76) patients treated with antiepileptic drugs, and vitamin D Group III (n=25) patients treated with antiepileptic drugs supplemented with vitamin D3 vitamin D. Each participant subjected to the electrocardiogram investigation at the time of entry into the study.

Results: Group III patients had a significant decrease of QRS complex, QRS dispersion QTcorrected, and TQ duration compared with Group II. Group I patients, had a significant increase of QRS complex duration, compared with Group II patients. Four patients of Group II showed a significant prolonged QT-interval in the QT nomogram. Three patients had a JT index (an indicator of ventricular hyperpolarization) more than the normal cutoff level of 112. The area under the curve of receiving operating characteristics showed significant favorable effects of vitamin D supplementation on the different variables of electrocardiograph.

Conclusion: Vitamin D supplementation may correct the changes in the electrocardiograph observed in idiopathic generalized tonic clonic seizure treated with antiepileptic medicines, and our observations warrant larger studies.

处方维生素D作为辅助治疗对癫痫患者心电图变化的益处。
背景:癫痫儿童和青少年血清维生素D水平明显偏低,这是由于抗癫痫药物对维生素D代谢的影响。这些患者有心血管事件的风险。目的:本研究旨在证明抗癫痫药物加维生素D治疗的癫痫患者与用抗癫痫药物治疗的癫痫患者相比无心电图改变。方法:本横断面研究纳入121例年龄< 18岁且有特发性全身性强直性阵挛发作史的癫痫患者。将患者分为未接受药物治疗的I组(n=20)、服用抗癫痫药物的II组(n=76)和服用维生素D的III组(n=25)。服用抗癫痫药物并补充维生素D3和维生素D的III组(n=25)。每个参与者在进入研究时都进行了心电图调查。结果:与II组比较,III组患者QRS复合体、QRS离散度、qq校正、TQ持续时间均显著降低。与II组患者相比,I组患者QRS综合持续时间明显增加。II组4例患者QT间期明显延长。3例患者JT指数(心室超极化指标)高于正常临界值112。接受工作特征曲线下面积显示,补充维生素D对心电图各变量均有显著的有利影响。结论:补充维生素D可以纠正使用抗癫痫药物治疗的特发性全局性强直性阵挛发作患者的心电图变化,我们的观察结果值得更大规模的研究。
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来源期刊
Current clinical pharmacology
Current clinical pharmacology PHARMACOLOGY & PHARMACY-
CiteScore
3.60
自引率
0.00%
发文量
0
期刊介绍: Current Clinical Pharmacology publishes frontier reviews on all the latest advances in clinical pharmacology. The journal"s aim is to publish the highest quality review articles in the field. Topics covered include: pharmacokinetics; therapeutic trials; adverse drug reactions; drug interactions; drug metabolism; pharmacoepidemiology; and drug development. The journal is essential reading for all researchers in clinical pharmacology.
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