mRNA Expression of Interferon Regulatory Factors during Acute Rejection of Liver Transplants in Patients with Autoimmune Hepatitis.

IF 0.3 Q4 TRANSPLANTATION

International Journal of Organ Transplantation Medicine Pub Date : 2018-01-01 Epub Date: 2018-02-01

M Nasiri, B Geramizadeh, S H Nabavizadeh, S A Male-Hosseini, M H Karimi, I Saadat

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引用次数: 0

Abstract

Background: Interferon regulatory factors (IRFs) can play a critical role in the regulation of many facets of innate and adaptive immune responses through transcriptional activation of type I interferons, other proinflammatory cytokines, and chemokines. However, their roles in transplantation immunity still remain to be elucidated.

Objective: To evaluate the time course of mRNA expression of all 9 members of IRFs family of transcription factors during liver allograft acute rejection.

Methods: Blood samples of 19 patients with autoimmune hepatitis receiving liver transplants were collected on days 1, 3, 5, and 7 post-transplantation. The patients were followed for 6 months after transplantation and divided into two groups of acute rejection (AR) (n=4) and non-acute rejection (non-AR) (n=15).

Results: All of the studied transcription factors were down-regulated in AR-group on days 3, 5, and 7 post-transplantation compared to non-AR group. The mean±SEM IRF5 on day 7 post-transplantation was significantly (p=0.005) lower in AR-group than in non-AR group (0.7±0.21 vs. 1.91±0.27, respectively); expression of other IRFs family members was not significantly different between the two groups on days 3, 5, and 7 post-transplantation.

Conclusion: IRF5 may have an important role during the acute rejection of liver transplants.

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自身免疫性肝炎患者肝移植急性排斥反应中干扰素调节因子mRNA的表达

背景:干扰素调节因子(IRFs)可以通过I型干扰素、其他促炎细胞因子和趋化因子的转录激活，在先天和适应性免疫反应的许多方面发挥关键作用。然而，它们在移植免疫中的作用仍有待阐明。目的:探讨同种异体肝移植急性排斥反应中IRFs家族9个转录因子mRNA表达的时间过程。方法:对19例接受肝移植的自身免疫性肝炎患者于肝移植后第1、3、5、7天采血。术后随访6个月，分为急性排斥反应(AR)组(n=4)和非急性排斥反应(non-AR)组(n=15)。结果:与非ar组相比，ar组在移植后第3、5、7天所有转录因子均下调。移植后第7天，ar组平均±SEM IRF5显著低于非ar组(分别为0.7±0.21比1.91±0.27)(p=0.005);在移植后第3、5、7天，两组间其他IRFs家族成员的表达无显著差异。结论:IRF5可能在肝移植急性排斥反应中起重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Organ Transplantation Medicine TRANSPLANTATION-

CiteScore

1.60

自引率

0.00%

发文量

审稿时长

12 weeks

期刊介绍： The International Journal of Organ Transplantation Medicine (IJOTM) is a quarterly peer-reviewed English-language journal that publishes high-quality basic sciences and clinical research on transplantation. The scope of the journal includes organ and tissue donation, procurement and preservation; surgical techniques, innovations, and novelties in all aspects of transplantation; genomics and immunobiology; immunosuppressive drugs and pharmacology relevant to transplantation; graft survival and prevention of graft dysfunction and failure; clinical trials and population analyses in the field of transplantation; transplant complications; cell and tissue transplantation; infection; post-transplant malignancies; sociological and ethical issues and xenotransplantation.