Barbara L. F. Kaplan
{"title":"Evaluation of Marijuana Compounds on Neuroimmune Endpoints in Experimental Autoimmune Encephalomyelitis","authors":"Barbara L. F. Kaplan","doi":"10.1002/cptx.43","DOIUrl":null,"url":null,"abstract":"<p>Cannabinoid compounds refer to a group of more than 60 plant-derived compounds in <i>Cannabis sativa</i>, more commonly known as marijuana. Exposure to marijuana and cannabinoid compounds has been increasing due to increased societal acceptance for both recreational and possible medical use. Cannabinoid compounds suppress immune function, and while this could compromise one's ability to fight infections, immune suppression is the desired effect for therapies for autoimmune diseases. It is critical, therefore, to understand the effects and mechanisms by which cannabinoid compounds alter immune function, especially immune responses induced in autoimmune disease. Therefore, this unit will describe induction and assessment of the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS), and its potential alteration by cannabinoid compounds. The unit includes three approaches to induce EAE, two of which provide correlations to two forms of MS, and the third specifically addresses the role of autoreactive T cells in EAE. © 2018 by John Wiley & Sons, Inc.</p>","PeriodicalId":72743,"journal":{"name":"Current protocols in toxicology","volume":"75 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2018-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/cptx.43","citationCount":"6","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current protocols in toxicology","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cptx.43","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 6
Abstract
Cannabinoid compounds refer to a group of more than 60 plant-derived compounds in Cannabis sativa, more commonly known as marijuana. Exposure to marijuana and cannabinoid compounds has been increasing due to increased societal acceptance for both recreational and possible medical use. Cannabinoid compounds suppress immune function, and while this could compromise one's ability to fight infections, immune suppression is the desired effect for therapies for autoimmune diseases. It is critical, therefore, to understand the effects and mechanisms by which cannabinoid compounds alter immune function, especially immune responses induced in autoimmune disease. Therefore, this unit will describe induction and assessment of the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS), and its potential alteration by cannabinoid compounds. The unit includes three approaches to induce EAE, two of which provide correlations to two forms of MS, and the third specifically addresses the role of autoreactive T cells in EAE. © 2018 by John Wiley & Sons, Inc.
大麻化合物对实验性自身免疫性脑脊髓炎神经免疫终点的影响
大麻素化合物是指大麻中60多种植物衍生的化合物,大麻通常被称为大麻。由于社会对娱乐和可能的医疗用途的接受程度越来越高,大麻和大麻素化合物的暴露程度越来越高。大麻素化合物抑制免疫功能,虽然这可能会损害一个人抵抗感染的能力,但免疫抑制是治疗自身免疫性疾病的理想效果。因此,了解大麻素化合物改变免疫功能的作用和机制,特别是自身免疫性疾病诱导的免疫反应是至关重要的。因此,本单元将描述多发性硬化症(MS)的实验性自身免疫性脑脊髓炎(EAE)模型的诱导和评估,以及大麻素化合物对其的潜在改变。该单元包括三种诱导EAE的方法,其中两种提供了两种MS形式的相关性,第三种专门针对自身反应性T细胞在EAE中的作用。©2018 by John Wiley &儿子,Inc。
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