Prolactin - Not Only a "Milk Hormone" Prolactin - Growth Hormone Relationships with Emphasis on Cancer.

4区医学 Q2 Medicine

Pediatric endocrinology reviews : PER Pub Date : 2018-03-01 DOI:10.17458/per.vol15.2018.fwl.prolactinrelationshipscancer

Alon Farfel, Haim Werner, Zvi Laron

引用次数: 1

Abstract

Prolactin (PRL) is a hormone secreted by lactotrophic cells in the anterior pituitary gland and its main function is the stimulation of lactogenesis. Research in recent years has revealed that PRL is also related to cancer development and plays a role in autoimmune diseases. PRL and Growth Hormone (GH) belong to the same cytokine family, both are, at least in part, secreted by the same somatomammotrophic cells in the anterior pituitary, and share similar signaling pathways. These common features raise the question whether PRL and GH share also joint actions especially in the pathogenesis of cancer.

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催乳素-不仅仅是“乳激素”催乳素-生长激素与癌症的关系。

催乳素(prolacactin, PRL)是由垂体前叶的乳营养细胞分泌的一种激素，其主要功能是刺激乳生成。近年来的研究表明，PRL也与癌症的发展有关，并在自身免疫性疾病中发挥作用。PRL和生长激素(Growth Hormone, GH)属于同一细胞因子家族，至少部分由垂体前叶相同的促生长细胞分泌，并具有相似的信号通路。这些共同的特征提出了一个问题，即PRL和GH是否也有共同的作用，特别是在癌症的发病机制中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric endocrinology reviews : PER Medicine-Endocrinology, Diabetes and Metabolism

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期刊介绍： PEDIATRIC ENDOCRINOLOGY REVIEWS (PER) publishes scholarly review articles in all areas of clinical and experimental Endocrinology, Diabetes, Nutrition and Metabolism. PER is intended for practicing pediatricians, pediatric endocrinologists, pediatric diabetologists, pediatric gastroenterologists, neonatologists, pediatric gynecologists, nutritionists, sport physicians and pediatricians-in-training. PER will also publish topics on specific subjects or as proceedings of scientific meetings in the above fields of interest. All articles, whether invited or direct contributions, are peer-reviewed. PER publishes correspondence, book reviews, a meeting calendar and meeting reports.