Determination of Parameters of Oxidative Stress in vitro Models of Neurodegenerative Diseases-A Review.

IF 3.2 Q2 Pharmacology, Toxicology and Pharmaceutics
Chistiane Mendes Feitosa, George Laylson da Silva Oliveira, Antonio do Nascimento Cavalcante, Soane Kaline Morais Chaves, Mahendra Rai
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引用次数: 18

Abstract

Oxidative stress is a major mechanism underlying the development of various neurodegenerative diseases (Alzheimer, Parkinson, Huntington and amyotrophic lateral sclerosis). Excessive formation of reactive oxygen species (ROS) and nitrogen (RNSs) can overburden the ability of the enzymatic antioxidant defense mechanisms (superoxide dismutase, catalase and glutathione reductase) and non-enzymatic (uric acid, ascorbic acid, α-tocopherol and reduced glutathione), causing the development of oxidative stress, and consequently, impairing the neuronal system cells by means of oxidative damage to a variety of important biological molecules such as lipids, DNA and proteins. Considering the importance of oxidative stress in neurodegenerative diseases, the present review aims to address the main parameters evaluated in in vitro studies on oxidative stress in different models of neurodegenerative diseases.The literary review was conducted through Pubmed, Science Direct, LILACS, Scielo and Google using following keywords: oxidative stress, neurodegenerative diseases and parameters of oxidative stress. We selected articles published between 2002 and 2017.The in vitro evaluation of the oxidative stress related parameters has provided a preliminary view about the pathogenesis of many neurodegenerative diseases (Alzheimer's, Parkinson's, Huntington's and Amyotrophic lateral sclerosis). In this way, it has demonstrated the mechanism of action of ROS/RNSs in these diseases by direct or indirect detection through several experimental procedures in vitro.

神经退行性疾病体外模型氧化应激参数的测定
氧化应激是各种神经退行性疾病(阿尔茨海默病、帕金森病、亨廷顿病和肌萎缩性侧索硬化症)发展的主要机制。活性氧(ROS)和活性氮(RNSs)的过量形成,可使酶促抗氧化防御机制(超氧化物歧化酶、过氧化氢酶和谷胱甘肽还原酶)和非酶促抗氧化防御机制(尿酸、抗坏血酸、α-生育酚和还原性谷胱甘肽)的能力过载,导致氧化应激的发生,从而通过对多种重要生物分子如脂质、DNA和蛋白质的氧化损伤,损害神经系统细胞。鉴于氧化应激在神经退行性疾病中的重要作用,本文综述了氧化应激在不同神经退行性疾病模型中的体外研究的主要参数。通过Pubmed、Science Direct、LILACS、Scielo和Google进行文献综述,关键词:氧化应激、神经退行性疾病和氧化应激参数。我们选择了2002年至2017年之间发表的文章。氧化应激相关参数的体外评价为许多神经退行性疾病(阿尔茨海默病、帕金森病、亨廷顿病和肌萎缩性侧索硬化症)的发病机制提供了初步的认识。这样,通过几种体外实验程序直接或间接检测,证明了ROS/RNSs在这些疾病中的作用机制。
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来源期刊
Current clinical pharmacology
Current clinical pharmacology PHARMACOLOGY & PHARMACY-
CiteScore
3.60
自引率
0.00%
发文量
0
期刊介绍: Current Clinical Pharmacology publishes frontier reviews on all the latest advances in clinical pharmacology. The journal"s aim is to publish the highest quality review articles in the field. Topics covered include: pharmacokinetics; therapeutic trials; adverse drug reactions; drug interactions; drug metabolism; pharmacoepidemiology; and drug development. The journal is essential reading for all researchers in clinical pharmacology.
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