In vitro And In vivo Immunomodulating Properties of Mesenchymal Stem Cells.

IF 4.2 Q3 Pharmacology, Toxicology and Pharmaceutics

Recent patents on inflammation & allergy drug discovery Pub Date : 2018-01-01 DOI:10.2174/1872213X12666180227105924

Divya Chaudhary, Raj N Trivedi, Ashima Kathuria, Tapas K Goswami, Rekha Khandia, Ashok Munjal

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引用次数: 10

Abstract

Background: Mesenchymal Stem Cells (MSCs) are self-renewing, multipotent progenitor cells with multilineage potential to differentiate into all cell types of mesodermal origin, such as adipocytes, osteocytes and chondrocytes. Mesenchymal Stem Cells (MSCs) are adult stem cells which can be isolated from human and animal sources.

Objective: Besides the differentiation potential of MSCs, these also regulate the immune response in numerous ailments. The present review expedites the immunomodulating prospective of MSCs.

Methods: Scrupulous search of the literature and patents available on MSCs and their role in the immunomodulation was carried out using Medline, PubMed, PubMed Central, Science Direct and other scientific databases. The retrieved information has been analyzed and compiled.

Results: MSCs have unique regulation of microenvironment in the host tissue by secreting cytokines and immune-receptors which results in immunomodulatory effects. MSCs can be used as an effective tool in the treatment of chronic diseases because of its property to secrete anti-inflammatory molecules, having multilineage potential and immunomodulation.

Conclusion: The present review is focused on the use of MSCs due to their unique immunomodulatory characteristics. MSCs reach to the site of inflammation and interact with immune cells to bring immunosuppressive and anti-inflammatory effects. Along with these unique therapeutic properties, MSCs may be a useful therapeutic approach for various disorders.

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间充质干细胞的体内外免疫调节特性。

背景:间充质干细胞(MSCs)是一种自我更新的多能祖细胞，具有多系分化潜能，可分化为所有中胚层来源的细胞类型，如脂肪细胞、骨细胞和软骨细胞。间充质干细胞(MSCs)是成体干细胞，可以从人和动物中分离出来。目的:骨髓间充质干细胞除了具有分化潜能外，还能调节多种疾病的免疫反应。本综述加速了MSCs免疫调节的前景。方法:利用Medline、PubMed、PubMed Central、Science Direct等科学数据库，对MSCs及其在免疫调节中的作用进行文献和专利检索。对检索到的信息进行了分析和编译。结果:间充质干细胞通过分泌细胞因子和免疫受体对宿主组织微环境具有独特的调节作用。间充质干细胞因其分泌抗炎分子、具有多谱系潜能和免疫调节作用等特性，可作为治疗慢性疾病的有效工具。结论:由于间充质干细胞具有独特的免疫调节特性，本文对其应用进行了综述。MSCs到达炎症部位，与免疫细胞相互作用，产生免疫抑制和抗炎作用。随着这些独特的治疗特性，间充质干细胞可能是一种有用的治疗各种疾病的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Recent patents on inflammation & allergy drug discovery PHARMACOLOGY & PHARMACY-

CiteScore

3.90

自引率

0.00%

发文量

期刊介绍： Recent Patents on Inflammation & Allergy Drug Discovery publishes review articles by experts on recent patents in the field of inflammation and allergy drug discovery e.g. on novel bioactive compounds, analogs and targets. A selection of important and recent patents in the field is also included in the journal. The journal is essential reading for all researchers involved in inflammation and allergy drug design and discovery.