The Promising Pharmacological Effects and Therapeutic/Medicinal Applications of Punica Granatum L. (Pomegranate) as a Functional Food in Humans and Animals.

IF 4.2 Q3 Pharmacology, Toxicology and Pharmaceutics
Muhammad Saeed, Muhammad Naveed, Jannat BiBi, Asghar A Kamboh, Muhammad A Arain, Qurban A Shah, Mahmoud Alagawany, Mohamed E A El-Hack, Mervat A Abdel-Latif, Mohd I Yatoo, Ruchi Tiwari, Sandip Chakraborty, Kuldeep Dhama
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引用次数: 67

Abstract

Background: Punica granatum L. (pomegranate), is a shrub mostly available in the Mediterranean Sea region. The fruits have gained the substantial attention among researchers due to their promising biological activities including anti-inflammatory, antibacterial, antidiarrheal, immune modulatory, antitumor, wound healing and antifungal that have been attributed to various constituents of seeds, bark, juice, pericarp, and leaf of this tree across the globe. The phenolic compounds of pomegranate have been documented to possess numbers of prophylactic and therapeutic utilities against various pathological infections as well as non-infectious disorders.

Objective: The current review expedites the pharmacological role of Punica granatum L. in curing elements related to infectious and non-infectious disorders.

Methods: The current review is based on literature and patents already available on various scientific databases highlighting the role of Punica granatum along with its therapeutic potentials against infectious and non-infectious disorders. The databases included under study were PubMed, Med line, PubMed Central, Science Direct and few other scientific databases. The information obtained through these diverse databases is compiled, critically interpreted and presented in the current study.

Results: Multi-dimensional beneficial application of pomegranate plant is recorded. The pomegranate seed oil has phytoestrogenic compounds and the fruit is rich in phenolic compounds with strong antioxidant activity. The fruit and bark of pomegranate are used against intestinal parasites, dysentery, and diarrhea in different animals and human models. Since the ancient time the juice and seeds had considered the best therapy for throat and heart disorders. Ellagic acid is one of the main components of pomegranate with potent antioxidant activity. Results from different studies reported that Punica granatum L or its byproducts can be used as natural food additives in human and animal nutrition in order to boost immunity, microbial safety and provide the housing environment without affecting body weight gain. In addition, Punica granatum L. byproducts can modulate immune function and gut microbiota of broiler chickens as well as reduce the odorous gas emissions from excreta. Naturally occurring polyphenols in a pomegranate can be a potential alternative medicine for the prevention of avian Colibacillosis diseases and can also be used as an intestine astringent to relieve diarrhea and enteritis in chickens.

Conclusion: The present review gives the insight towards major components of pomegranate as well as their pharmacological activities against pathological disorders. In spite of many beneficial properties of Punica granatum L., more research evidence on a molecular basis is needed to find out the molecular mechanism of action in various animals and human models to validate the usefulness of Punica granatum L. as a potent therapeutic agent.

石榴(Punica Granatum L.,石榴)作为一种功能食品在人与动物中的药理作用和治疗/药物应用前景
背景:石榴是一种灌木,主要分布在地中海地区。由于其具有抗炎、抗菌、止泻、免疫调节、抗肿瘤、伤口愈合和抗真菌等生物活性,其果实受到了研究人员的广泛关注,这些活性被认为是来自于全球各地的这种树的种子、树皮、果汁、果皮和叶子的各种成分。石榴的酚类化合物已被证明对各种病理性感染和非感染性疾病具有预防和治疗作用。目的:综述石榴在感染性和非感染性疾病相关因素中的药理作用。方法:目前的综述是基于各种科学数据库中已有的文献和专利,强调了石榴的作用以及它对传染性和非传染性疾病的治疗潜力。纳入研究的数据库包括PubMed、Med line、PubMed Central、Science Direct和其他一些科学数据库。通过这些不同的数据库获得的信息被编译,批判性地解释并呈现在当前的研究中。结果:记录了石榴植物的多维有益应用。石榴籽油含有植物雌激素化合物,石榴果实含有丰富的酚类化合物,具有很强的抗氧化活性。石榴的果实和树皮在不同的动物和人类模型中被用来治疗肠道寄生虫、痢疾和腹泻。自古以来,果汁和种子就被认为是治疗咽喉和心脏疾病的最佳方法。鞣花酸是石榴的主要成分之一,具有很强的抗氧化活性。不同的研究结果表明,石榴或其副产品可以作为人类和动物营养的天然食品添加剂,以提高免疫力,微生物安全性和提供居住环境,而不影响体重增加。此外,石榴副产物还能调节肉鸡的免疫功能和肠道菌群,减少粪便中恶臭气体的排放。石榴中天然存在的多酚可以作为预防禽大肠杆菌病的潜在替代药物,也可以作为肠道收敛剂来缓解鸡的腹泻和肠炎。结论:本文综述了石榴的主要成分及其抗病理疾病的药理作用。尽管石榴有许多有益的特性,但需要更多的分子基础研究证据来发现各种动物和人体模型的分子作用机制,以验证石榴作为一种有效的治疗剂的有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.90
自引率
0.00%
发文量
0
期刊介绍: Recent Patents on Inflammation & Allergy Drug Discovery publishes review articles by experts on recent patents in the field of inflammation and allergy drug discovery e.g. on novel bioactive compounds, analogs and targets. A selection of important and recent patents in the field is also included in the journal. The journal is essential reading for all researchers involved in inflammation and allergy drug design and discovery.
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