Cristina Fernández, Juan Ramón Larrubia, Ana Avellón, Nora Mariela Martínez, Antonio Gómez, Alejandro González Praetorius
{"title":"[Severe acute hepatitis by delta virus superinfection: diagnostic significance of molecular biology.]","authors":"Cristina Fernández, Juan Ramón Larrubia, Ana Avellón, Nora Mariela Martínez, Antonio Gómez, Alejandro González Praetorius","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>HDV infection may occur within a primary HBV infection (co-infection) or by sub sequent acquisition ofthe virus in patients with chronic hepatitis B (superinfection). Acute HDV infection is rarely diagnosed. Since cero conversion usually takes place about six weeks after viral infection, early diagnosis requires the use of direct diagnostic techniques, such as antigen HD V (HDAg) detection, or genomic amplification by means of molecular biology methods (RT-PCR). Here were port the case of a patient with chronic HBV infection that develops a severe acute hepatitis due to VHD superinfec- tion only detected by molecular biology.</p>","PeriodicalId":35700,"journal":{"name":"Acta Gastroenterologica Latinoamericana","volume":"46 1","pages":"35-37"},"PeriodicalIF":0.0000,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Gastroenterologica Latinoamericana","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
HDV infection may occur within a primary HBV infection (co-infection) or by sub sequent acquisition ofthe virus in patients with chronic hepatitis B (superinfection). Acute HDV infection is rarely diagnosed. Since cero conversion usually takes place about six weeks after viral infection, early diagnosis requires the use of direct diagnostic techniques, such as antigen HD V (HDAg) detection, or genomic amplification by means of molecular biology methods (RT-PCR). Here were port the case of a patient with chronic HBV infection that develops a severe acute hepatitis due to VHD superinfec- tion only detected by molecular biology.
HDV感染可能发生在原发性HBV感染(合并感染)中,也可能发生在慢性乙型肝炎患者随后获得病毒(重复感染)中。急性HDV感染很少被诊断出来。由于cero转化通常在病毒感染后约6周发生,因此早期诊断需要使用直接诊断技术,例如抗原HD V (HDAg)检测,或通过分子生物学方法(RT-PCR)进行基因组扩增。这里有一例慢性HBV感染患者由于VHD重叠感染而发展为严重急性肝炎的病例-仅通过分子生物学检测。
期刊介绍:
Está dedicada a la investigación clínica y básica sobre todos los aspectos del aparato digestivo, incluídos el hígado, el páncreas y la nutrición, en seres humanos adultos y niños, animales de experimentación o sistemas celulares.