Improved survival rate after myocardial infarction using an inducible cholesterol efflux (iCE) peptide: FAMP

International journal of cardiology. Heart & vessels Pub Date : 2014-09-01 DOI:10.1016/j.ijchv.2014.05.005

Eiji Yahiro , Yoshinari Uehara , Emi Kawachi , Setsuko Ando , Shin-ichiro Miura , Keijiro Saku

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引用次数: 4

Abstract

Background

There have been no previous reports that apolipoprotein (apo) A-I mimetic peptide improves survival rate after myocardial infarction (MI).

Method and results

Male C57Bl/6J mice were subjected to left coronary artery permanent ligation as a model of MI. We synthesized a novel 24-amino acid apoA-I mimetic peptide-type5 (FAMP5), which potently removes cholesterol via specific ATP-binding cassette transporter A1 (ABCA1). FAMP5 was associated with a significantly improved survival rate by protecting against cardiac rupture compared to the control. mRNA levels for eNOS, Gata-4, CTGF and ANP were significantly increased in the hearts of the FAMP5-treated group, while that for MCP-1 decreased.

Conclusion

This is the first report that high-density lipoprotein (HDL) therapy with FAMP5 improved the survival rate after MI.

Abstract Image

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诱导型胆固醇外排肽:FAMP提高心肌梗死后生存率

背景:载脂蛋白(apo) A-I模拟肽可提高心肌梗死(MI)后生存率，目前尚无相关报道。方法和结果将C57Bl/6J小鼠作为心肌梗死模型进行左冠状动脉永久性结扎。我们合成了一种新的24个氨基酸的apoA-I模拟肽- 5 (FAMP5)，它通过特异性atp结合盒转运体A1 (ABCA1)有效地去除胆固醇。与对照组相比，FAMP5通过防止心脏破裂而显著提高了生存率。famp5处理组心脏eNOS、Gata-4、CTGF和ANP mRNA水平显著升高，MCP-1 mRNA水平降低。结论用FAMP5治疗高密度脂蛋白(HDL)可提高心肌梗死患者的生存率，这是首次报道。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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International journal of cardiology. Heart & vessels

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