Molecular epidemiology of the community-associated methicillin-resistant staphylococcus aureus clones: a synthetic review.

Clujul medical (1957) Pub Date : 2018-01-01 Epub Date: 2018-01-15 DOI:10.15386/cjmed-807
Lia Monica Junie, Ionuţ Isaia Jeican, Luminiţa Matroş, Stanca Lucia Pandrea
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引用次数: 15

Abstract

The article presents a synthetic molecular characterization of the methicillin-resistant Staphylococcus aureus and describes the most important community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) clones that circulate nowadays in the world: the main molecular and epidemiological characteristics, as well as notions related to the clinic of infections produced by these clones and their antibiotic resistance spectrum. The predominant clone of CA-MRSA in North America is USA300 - ST8-IV in North America, in Australia - Queensland (Qld) MRSA (ST93-IV), in Europe - ST80-IV, in Asia there is a high heterogeneity of clones population, in Africa the distribution of CA-MRSA clones is unclear, and in South America - USA 1100 and USA300-Latin American variant are predominant. The molecular diagnosis is performed by highly specialized institutions. The knowledge of clones allows the study of antibiotic resistance spectrum for each one, a fact of great importance for medical practice. Molecular epidemiology of the CA-MRSA shows that lowly restricted sales of antibiotics in shops and pharmacies, as well as medical prescribing practices without a laboratory investigation, especially in Eastern Europe and Asia, contribute to the development of new MRSA clones with increased resistance to antibiotics.

Abstract Image

社区相关耐甲氧西林金黄色葡萄球菌克隆的分子流行病学综述
本文介绍了耐甲氧西林金黄色葡萄球菌的合成分子特征,并介绍了目前世界上流行的最重要的社区获得性耐甲氧西林金黄色葡萄球菌(CA-MRSA)克隆的主要分子和流行病学特征,以及这些克隆产生的临床感染的相关概念和耐药谱。CA-MRSA在北美的优势克隆为USA300- ST8-IV,在澳大利亚-昆士兰(Qld) MRSA (ST93-IV),在欧洲- ST80-IV,在亚洲存在较高的克隆种群异质性,在非洲CA-MRSA克隆分布不清楚,在南美洲- USA 1100和USA300-拉丁美洲变体占主导地位。分子诊断由高度专业化的机构进行。克隆的知识允许研究抗生素耐药谱的每一个,这对医疗实践非常重要的事实。CA-MRSA的分子流行病学表明,商店和药房对抗生素的销售限制较低,以及未经实验室调查的医疗处方做法,特别是在东欧和亚洲,导致了对抗生素耐药性增强的新的MRSA克隆的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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