Effects on Sperms' Quality of Selegiline in Aged Rats.

Q2 Pharmacology, Toxicology and Pharmaceutics

Open Medicinal Chemistry Journal Pub Date : 2017-11-30 eCollection Date: 2017-01-01 DOI:10.2174/1874104501711010138

Huba Kalász, Julianna Thuróczy, Gellért Karvaly, Lajos Balogh, István Gyertyán, Edit Tóth-Molnár, Ernest Adeghate, Kornélia Tekes

引用次数: 1

Abstract

Background: Selegiline is used to treat Parkinsonian patients. Other indications of its use have recently been discovered.

Objective: Scouting special and beneficial side effects of selegiline treatment.

Method: Two-year old male Wistar rats were daily treated with 0.25 mg/kg of selegiline s.c. (subcutaneous injection). The rats were sacrificed following a four-weeks' treatment.

Results: Mass of testes, number of sperms, progressive motility of sperms, and their viability definitely increased.

Conclusion: Selegiline can successfully be used to stop/counterbalance certain symptoms of aging.

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斯来吉兰对老龄大鼠精子质量的影响。

背景:斯来吉兰用于治疗帕金森病患者。最近还发现了使用它的其他迹象。目的:发现司来吉兰治疗的特殊有益副作用。方法:2岁雄性Wistar大鼠每日皮下注射0.25 mg/kg斯来吉兰s.c。这些大鼠在治疗四周后被处死。结果:睾丸质量、精子数量、精子进行性运动能力和活力明显提高。结论:司来吉兰可以成功地阻止/平衡某些衰老症状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Medicinal Chemistry Journal Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

4.40

自引率

0.00%

发文量