Scarless wound healing: Transitioning from fetal research to regenerative healing.

Q1 Biochemistry, Genetics and Molecular Biology

Wiley Interdisciplinary Reviews: Developmental Biology Pub Date : 2018-03-01 Epub Date: 2018-01-09 DOI:10.1002/wdev.309

Alessandra L Moore, Clement D Marshall, Leandra A Barnes, Matthew P Murphy, Ryan C Ransom, Michael T Longaker

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Abstract

Since the discovery of scarless fetal skin wound healing, research in the field has expanded significantly with the hopes of advancing the finding to adult human patients. There are several differences between fetal and adult skin that have been exploited to facilitate scarless healing in adults including growth factors, cytokines, and extracellular matrix substitutes. However, no one therapy, pathway, or cell subtype is sufficient to support scarless wound healing in adult skin. More recently, products that contain or mimic fetal and adult uninjured dermis were introduced to the wound healing market with promising clinical outcomes. Through our review of the major experimental targets of fetal wound healing, we hope to encourage research in areas that may have a significant clinical impact. Additionally, we will investigate therapies currently in clinical use and evaluate whether they represent a legitimate advance in regenerative medicine or a vulnerary agent. WIREs Dev Biol 2018, 7:e309. doi: 10.1002/wdev.309 This article is categorized under: Adult Stem Cells, Tissue Renewal, and Regeneration > Regeneration Plant Development > Cell Growth and Differentiation Adult Stem Cells, Tissue Renewal, and Regeneration > Environmental Control of Stem Cells.

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无疤痕伤口愈合：从胎儿研究过渡到再生愈合。

自发现胎儿皮肤伤口无疤痕愈合以来，该领域的研究已大幅扩展，希望能将这一发现推广到成人患者身上。胎儿皮肤和成人皮肤之间存在一些差异，人们利用这些差异促进成人皮肤的无疤痕愈合，包括生长因子、细胞因子和细胞外基质替代物。然而，没有一种疗法、途径或细胞亚型足以支持成人皮肤的无疤痕伤口愈合。最近，含有或模拟胎儿和成人未损伤真皮的产品被引入伤口愈合市场，并取得了良好的临床效果。我们希望通过对胎儿伤口愈合主要实验目标的回顾，鼓励对可能产生重大临床影响的领域进行研究。此外，我们还将调查目前临床使用的疗法，并评估这些疗法是再生医学的合法进步，还是一种漏洞剂。WIREs Dev Biol 2018, 7:e309. doi: 10.1002/wdev.309 本文归类于：成体干细胞、组织更新和再生 > 再生植物发育 > 细胞生长和分化成体干细胞、组织更新和再生 > 干细胞的环境控制。

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来源期刊

Wiley Interdisciplinary Reviews: Developmental Biology DEVELOPMENTAL BIOLOGY-

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期刊介绍： Developmental biology is concerned with the fundamental question of how a single cell, the fertilized egg, ultimately produces a complex, fully patterned adult organism. This problem is studied on many different biological levels, from the molecular to the organismal. Developed in association with the Society for Developmental Biology, WIREs Developmental Biology will provide a unique interdisciplinary forum dedicated to fostering excellence in research and education and communicating key advances in this important field. The collaborative and integrative ethos of the WIREs model will facilitate connections to related disciplines such as genetics, systems biology, bioengineering, and psychology. The topical coverage of WIREs Developmental Biology includes: Establishment of Spatial and Temporal Patterns; Gene Expression and Transcriptional Hierarchies; Signaling Pathways; Early Embryonic Development; Invertebrate Organogenesis; Vertebrate Organogenesis; Nervous System Development; Birth Defects; Adult Stem Cells, Tissue Renewal and Regeneration; Cell Types and Issues Specific to Plants; Comparative Development and Evolution; and Technologies.