Efficacy of Modified Bioactive Glass for Dentin Remineralization and Obstruction of Dentinal Tubules.

Mahshid Saffarpour, Maryam Mohammadi, Mohammadreza Tahriri, Azadeh Zakerzadeh
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Abstract

Objectives: This study assessed the efficacy of modified bioactive glass (MBG) for dentin remineralization and obstruction of dentinal tubules.

Materials and methods: Thirty-six dentin discs were made from 20 third molars and were stored in 12% lactic acid solution for two weeks to induce demineralization. The samples were divided into three groups (n=12): 1- BG, 2- BG modified with 5% strontium (Sr) and 3- BG modified with 10% Sr. After applying the BG, the samples were stored in artificial saliva for 7, 14 and 21 days. Attenuated Total Reflection-Fourier Transform Infrared Spectroscopy (ATR-FTIR), X-ray Diffraction (XRD) analysis, Scanning Electron Microscopy (SEM), and Energy-Dispersive X-ray (EDX) analysis were used to assess remineralization. Also, 6 dentin discs were divided into three groups of BG, BG modified with 5% Sr and BG modified with 10% Sr, to examine tubular occlusion. The discs were etched using 0.5M of EDTA for two minutes and were stored in artificial saliva for 7 days. Changes in dentin surface morphology were evaluated under SEM.

Results: Group 3 showed high rates of remineralization at days 7 and 14, although the rate decreased at day 21. Group 2 exhibited high rates of remineralization at days 7, 14 and 21. Dentinal tubules were partially occluded by BG and BG modified with 5% Sr, while they were almost completely obstructed after the use of BG modified with 10% Sr.

Conclusions: Strontium increases remineralization. Addition of 10% Sr to BG enhances apatite formation; however, the apatite dissolves over time. Addition of 5% Sr to BG stabilizes the apatite lattice and increases the remineralization.

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改性生物活性玻璃对牙本质再矿化和阻塞牙本质小管的功效
研究目的本研究评估了改性生物活性玻璃(MBG)对牙本质再矿化和阻塞牙本质小管的功效:从 20 颗第三磨牙上制作了 36 个牙本质盘,并在 12% 的乳酸溶液中保存两周以诱导脱矿化。样本分为三组(n=12):使用 BG 后,样品在人工唾液中分别保存 7、14 和 21 天。使用衰减全反射-傅立叶变换红外光谱(ATR-FTIR)、X 射线衍射(XRD)分析、扫描电子显微镜(SEM)和能量色散 X 射线(EDX)分析来评估再矿化情况。此外,还将 6 个牙本质圆盘分为三组,即 BG、用 5% Sr 修饰的 BG 和用 10% Sr 修饰的 BG,以检查管状咬合。牙盘用 0.5M EDTA 蚀刻两分钟,然后在人工唾液中保存 7 天。在扫描电镜下评估牙本质表面形态的变化:第 3 组在第 7 天和第 14 天显示出较高的再矿化率,但第 21 天时再矿化率有所下降。第 2 组在第 7、14 和 21 天的再矿化率较高。牙本质小管被 BG 和用 5%锶修饰的 BG 部分阻塞,而使用用 10%锶修饰的 BG 后,牙本质小管几乎完全阻塞:结论:锶能增加再矿化。在 BG 中添加 10%的锶可促进磷灰石的形成,但磷灰石会随着时间的推移而溶解。在 BG 中添加 5%的锶可稳定磷灰石晶格并增加再矿化。
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