Effect of alternate day fasting on markers of bone metabolism: An exploratory analysis of a 6-month randomized controlled trial.

Q3 Medicine

Nutrition and Healthy Aging Pub Date : 2017-12-07 DOI:10.3233/NHA-170031

Adrienne Barnosky, Cynthia M Kroeger, John F Trepanowski, Monica C Klempel, Surabhi Bhutani, Kristin K Hoddy, Kelsey Gabel, Sue A Shapses, Krista A Varady

{"title":"Effect of alternate day fasting on markers of bone metabolism: An exploratory analysis of a 6-month randomized controlled trial.","authors":"Adrienne Barnosky, Cynthia M Kroeger, John F Trepanowski, Monica C Klempel, Surabhi Bhutani, Kristin K Hoddy, Kelsey Gabel, Sue A Shapses, Krista A Varady","doi":"10.3233/NHA-170031","DOIUrl":null,"url":null,"abstract":"Background: Alternate day fasting (ADF) is a novel diet therapy that reduces body weight, but its effect on bone health remains unknown.Objective: This study examined the impact of ADF versus traditional daily calorie restriction (CR) on markers of bone metabolism in a 6-month randomized controlled trial.Methods: Overweight and obese subjects (n = 100) were randomized to 1 of 3 groups for 6 months: 1) ADF (25% energy intake fast day, alternated with 125% intake feast day; 2) CR (75% intake every day); or 3) control (usual intake every day).Results: Body weight decreased similarly (P < 0.001) by ADF (-7.8±1.2%) and CR (-8.8±1.5%), relative to controls by month 6. Lean mass, total body bone mineral content and total body bone mineral density remained unchanged in all groups. Circulating osteocalcin, bone alkaline phosphatase, and C-terminal telopeptide type I collagen (CTX) did not change in any group. IGF-1 increased (P < 0.01) in the CR group, with no change in the ADF or control group. When the data were sub-analyzed according to menopausal status, there were no differences between premenopausal or postmenopausal women for any marker of bone metabolism.Conclusion: These findings suggest that 6 months of ADF does not have any deleterious impact on markers of bone metabolism in obese adults with moderate weight loss.","PeriodicalId":37419,"journal":{"name":"Nutrition and Healthy Aging","volume":"4 3","pages":"255-263"},"PeriodicalIF":0.0000,"publicationDate":"2017-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/NHA-170031","citationCount":"25","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nutrition and Healthy Aging","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3233/NHA-170031","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 25

Abstract

Background: Alternate day fasting (ADF) is a novel diet therapy that reduces body weight, but its effect on bone health remains unknown.

Objective: This study examined the impact of ADF versus traditional daily calorie restriction (CR) on markers of bone metabolism in a 6-month randomized controlled trial.

Methods: Overweight and obese subjects (n = 100) were randomized to 1 of 3 groups for 6 months: 1) ADF (25% energy intake fast day, alternated with 125% intake feast day; 2) CR (75% intake every day); or 3) control (usual intake every day).

Results: Body weight decreased similarly (P < 0.001) by ADF (-7.8±1.2%) and CR (-8.8±1.5%), relative to controls by month 6. Lean mass, total body bone mineral content and total body bone mineral density remained unchanged in all groups. Circulating osteocalcin, bone alkaline phosphatase, and C-terminal telopeptide type I collagen (CTX) did not change in any group. IGF-1 increased (P < 0.01) in the CR group, with no change in the ADF or control group. When the data were sub-analyzed according to menopausal status, there were no differences between premenopausal or postmenopausal women for any marker of bone metabolism.

Conclusion: These findings suggest that 6 months of ADF does not have any deleterious impact on markers of bone metabolism in obese adults with moderate weight loss.

Abstract Image

查看原文本刊更多论文

隔日禁食对骨代谢标志物的影响:一项为期6个月的随机对照试验的探索性分析。

背景:隔日禁食(ADF)是一种新的饮食疗法，可减轻体重，但其对骨骼健康的影响尚不清楚。目的:在一项为期6个月的随机对照试验中，研究了ADF与传统的每日卡路里限制(CR)对骨代谢标志物的影响。方法:超重和肥胖受试者(n = 100)随机分为3组中的1组，为期6个月:1)ADF(25%能量摄入禁食日，与125%能量摄入丰宴日交替进行;2) CR(每天摄入75%);或3)控制(每天正常摄入)。结果:体重下降相似(P P结论:这些发现表明，6个月的ADF对中度体重减轻的肥胖成年人的骨代谢标志物没有任何有害影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nutrition and Healthy Aging Agricultural and Biological Sciences-Food Science

CiteScore

1.70

自引率

0.00%

发文量

期刊介绍： Nutrition and Healthy Aging is an international forum for research on nutrition as a means of promoting healthy aging. It is particularly concerned with the impact of nutritional interventions on the metabolic and molecular mechanisms which modulate aging and age-associated diseases, including both biological responses on the part of the organism itself and its micro biome. Results emanating from both model organisms and clinical trials will be considered. With regards to the latter, the journal will be rigorous in only accepting for publication well controlled, randomized human intervention trials that conform broadly with the current EFSA and US FDA guidelines for nutritional clinical studies. The journal will publish research articles, short communications, critical reviews and conference summaries, whilst open peer commentaries will be welcomed.