Treatment of Alopecia Areata with Simvastatin/Ezetimibe

Q2 Medicine

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2018-01-01 DOI:10.1016/j.jisp.2017.10.013

Jessica Cervantes , Joaquin J. Jimenez , Gina M. DelCanto , Antonella Tosti

引用次数: 48

Abstract

Alopecia areata (AA) is an autoimmune disorder characterized by T lymphocytic infiltrates around the bulbar region of hair follicles. Statins have surfaced as potential therapeutic agents for AA, partly because of their modulation of the JAK/STAT pathway. Some data indicate that statins are a possible option for acute, but not chronic, longstanding AA. Animal studies suggest that treatment with statins increases CD4⁺/CD25⁺/Foxp3⁺ populations in AA-affected mice.

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辛伐他汀/依折替米治疗斑秃

斑秃(AA)是一种自身免疫性疾病，其特征是T淋巴细胞浸润在毛囊球区周围。他汀类药物已成为AA的潜在治疗药物，部分原因是它们可以调节JAK/STAT通路。一些数据表明，他汀类药物是急性而非慢性长期AA的可能选择。动物研究表明，他汀类药物治疗可增加aa感染小鼠的CD4+/CD25+/Foxp3+数量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Investigative Dermatology Symposium Proceedings 医学-皮肤病学

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期刊介绍： Journal of Investigative Dermatology Symposium Proceedings (JIDSP) publishes peer-reviewed, invited papers relevant to all aspects of cutaneous biology and skin disease. Papers in the JIDSP are often initially presented at a scientific meeting. Potential topics include biochemistry, biophysics, carcinogenesis, cellular growth and regulation, clinical research, development, epidemiology and other population-based research, extracellular matrix, genetics, immunology, melanocyte biology, microbiology, molecular and cell biology, pathology, pharmacology and percutaneous absorption, photobiology, physiology, and skin structure.