Dermal fibroblast in cutaneous development and healing.

Q1 Biochemistry, Genetics and Molecular Biology

Wiley Interdisciplinary Reviews: Developmental Biology Pub Date : 2018-03-01 Epub Date: 2017-12-15 DOI:10.1002/wdev.307

Venkata Thulabandu, Demeng Chen, Radhika P Atit

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引用次数: 131

Abstract

The skin is the largest organ of the body and is composed of two layers: the overlying epidermis and the underlying dermis. The dermal fibroblasts originate from distinct locations of the embryo and contain the positional identity and patterning information in the skin. The dermal fibroblast progenitors differentiate into various cell types that are fated to perform specific functions such as hair follicle initiation and scar formation during wound healing. Recent studies have revealed the heterogeneity and plasticity of dermal fibroblasts within skin, which has implications for skin disease and tissue engineering. The objective of this review is to frame our current understanding and provide new insights on the origin and differentiation of dermal fibroblasts and their function during cutaneous development and healing. WIREs Dev Biol 2018, 7:e307. doi: 10.1002/wdev.307 This article is categorized under: Birth Defects > Organ Anomalies Signaling Pathways > Cell Fate Signaling Adult Stem Cells, Tissue Renewal, and Regeneration > Regeneration Nervous System Development > Vertebrates: Regional Development.

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真皮成纤维细胞在皮肤发育和愈合中的作用。

皮肤是人体最大的器官，由两层组成:上表皮和下真皮层。真皮成纤维细胞起源于胚胎的不同位置，并包含皮肤中的位置身份和模式信息。真皮成纤维细胞祖细胞分化成各种类型的细胞，这些细胞注定具有特定的功能，如毛囊的形成和伤口愈合过程中的疤痕形成。最近的研究揭示了皮肤内真皮成纤维细胞的异质性和可塑性，这对皮肤疾病和组织工程具有重要意义。这篇综述的目的是构建我们目前的认识，并提供关于真皮成纤维细胞的起源和分化及其在皮肤发育和愈合中的功能的新见解。中国生物医学工程学报，2018,32(1):391 - 391。doi: 10.1002 / wdev.307本文分类如下:出生缺陷>器官异常信号通路>细胞命运信号转导成体干细胞、组织更新和再生>再生神经系统发育>脊椎动物:区域发育。

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来源期刊

Wiley Interdisciplinary Reviews: Developmental Biology DEVELOPMENTAL BIOLOGY-

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期刊介绍： Developmental biology is concerned with the fundamental question of how a single cell, the fertilized egg, ultimately produces a complex, fully patterned adult organism. This problem is studied on many different biological levels, from the molecular to the organismal. Developed in association with the Society for Developmental Biology, WIREs Developmental Biology will provide a unique interdisciplinary forum dedicated to fostering excellence in research and education and communicating key advances in this important field. The collaborative and integrative ethos of the WIREs model will facilitate connections to related disciplines such as genetics, systems biology, bioengineering, and psychology. The topical coverage of WIREs Developmental Biology includes: Establishment of Spatial and Temporal Patterns; Gene Expression and Transcriptional Hierarchies; Signaling Pathways; Early Embryonic Development; Invertebrate Organogenesis; Vertebrate Organogenesis; Nervous System Development; Birth Defects; Adult Stem Cells, Tissue Renewal and Regeneration; Cell Types and Issues Specific to Plants; Comparative Development and Evolution; and Technologies.