The Protective Effect of Hydroalcoholic Extract of Zingiber officinale Roscoe (Ginger) on Ethanol-Induced Reproductive Toxicity in Male Rats.

Journal of Evidence-Based Complementary & Alternative Medicine Pub Date : 2017-10-01 Epub Date: 2017-01-17 DOI:10.1177/2156587216687696

Abolfazl Akbari, Khadijeh Nasiri, Mojtaba Heydari, Seyed Hamdollah Mosavat, Aida Iraji

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Abstract

This study was conducted to evaluate the prophylactic effect of ginger extract on ethanol-induced reproductive toxicity in male rats. Twenty-eight adult male Sprague-Dawley rats were randomly divided into 4 groups and treated daily for 28 days as follows: control, control-ginger (1 g/kg of body weight [BW]/day by gavage), ethanol group (ethanol 4 g/kg of BW/day by gavage), and ginger-ethanol group. At the end of the experiment, all the rats were sacrificed and their testes were removed and used for measurement of the total homocysteine (tHcy), trace elements, antioxidant enzymes activity, and malondialdehyde (MDA). The results in the ethanol group indicate that ethanol decreased antioxidant enzymes activity and increased MDA and tHcy compared with the control groups ( P < .05). In ginger-ethanol group, ginger improved antioxidant enzymes activity and reduced tHcy and MDA compared to ethanol group ( P < .05). It can be concluded that ginger protects the ethanol-induced testicular damage and improves the hormonal levels, trace elements, antioxidant enzymes activity, and decreases tHcy and MDA.

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生姜水醇提取物对乙醇诱导的雄性大鼠生殖毒性的保护作用

本研究旨在评估生姜提取物对乙醇诱导的雄性大鼠生殖毒性的预防作用。研究人员将 28 只成年雄性 Sprague-Dawley 大鼠随机分为 4 组，每天给药 28 天，分别为对照组、对照组-生姜组（每天给药 1 克/千克体重）、乙醇组（每天给药 4 克/千克体重）和生姜-乙醇组。实验结束后，所有大鼠均被处死，并切除睾丸，用于测量总同型半胱氨酸（tHcy）、微量元素、抗氧化酶活性和丙二醛（MDA）。乙醇组的结果表明，与对照组相比，乙醇降低了抗氧化酶的活性，增加了 MDA 和 tHcy（P < .05）。在生姜-乙醇组中，与乙醇组相比，生姜提高了抗氧化酶的活性，降低了 tHcy 和 MDA ( P < .05)。由此可以得出结论，生姜能保护乙醇引起的睾丸损伤，改善激素水平、微量元素、抗氧化酶活性，降低 tHcy 和 MDA。

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来源期刊

Journal of Evidence-Based Complementary & Alternative Medicine

自引率

0.00%

发文量

审稿时长

15 weeks

期刊介绍： The Journal of Evidence-Based Integrative Medicine ((JEBIM)), published previously as the Journal of Evidence-Based Complementary and Alternative Medicine (JEBCAM) and also as Complementary Health Practice Review (CHPR). The Journal of Evidence-Based Integrative Medicine (JEBIM) is an interdisciplinary, peer-reviewed, open access, biomedical journal whose aim is to create a global platform for hypothesis-driven and evidence-based research in all fields of integrative medicine. The journal’s objective is to publish papers which impart scientific validity to Integrative Medicine methods that are indispensable and inevitable in today’s world. All papers will be peer reviewed by experts in their respective fields, and papers will be accepted based on their scientific merit. It is the goal of the Journal to help remove the “myth” and provide scientific rationale for the various methodologies and theories of Integrative Medicine. All submissions will be reviewed based on their scientific merit and only papers with sound study design, valid statistical analyses and logical conclusions will be accepted. Topics include, but are not limited to: Traditional Eastern and Western medicine Nutrition therapy and supplementation Massage Therapy Non-traditional treatments Preventative medicine Integrative health and medicine Mindfulness Yoga.