Exploring the activities of ruthenium nanomaterials as reactive oxygen species scavengers.

Q2 Biochemistry, Genetics and Molecular Biology

Journal of Environmental Science and Health Part C-Environmental Carcinogenesis & Ecotoxicology Reviews Pub Date : 2017-10-02 Epub Date: 2017-12-08 DOI:10.1080/10590501.2017.1391516

Gao-Juan Cao, Xiumei Jiang, Hui Zhang, Jiwen Zheng, Timothy R Croley, Jun-Jie Yin

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引用次数: 13

Abstract

Research on noble metal nanoparticles (NPs) able to scavenge reactive oxygen species (ROS) has undergone a tremendous growth recently. However, the interactions between ruthenium nanoparticles (Ru NPs) and ROS have never been systematically explored thus far. This research focused on the decomposition of hydrogen peroxide (H₂O₂), scavenging of hydroxyl radicals (^•OH), superoxide radical (O₂^•-), singlet oxygen (¹O₂), 2,2'-azino-bis(3-ethylbenzenothiazoline- 6-sulfonic acid ion (ABTS^•+), and 1,1-diphenyl-2-picrylhydrazyl radical (^•DPPH) in the presence of commercial Ru NPs using the electron spin resonance technique. In vitro cell studies demonstrated that Ru NPs have excellent biocompatibility and exert a cytoprotective effect against oxidative stress. These findings may spark fresh enthusiasm for the applications of Ru NPs under relevant physiologically conditions.

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探讨钌纳米材料作为活性氧清除剂的活性。

近年来，对清除活性氧(ROS)的贵金属纳米颗粒的研究得到了极大的发展。然而，迄今为止，钌纳米颗粒(Ru NPs)与活性氧之间的相互作用尚未被系统地探索过。本研究主要研究了利用电子自旋共振技术在商业钌NPs存在下分解过氧化氢(H2O2)、清除羟基自由基(•OH)、超氧自由基(O2•-)、单重态氧(1O2)、2,2′-氮基-双(3-乙基苯噻唑啉- 6-磺酸离子(ABTS•+)和1,1-二苯基-2-吡啶肼基自由基(•DPPH)。体外细胞研究表明，Ru NPs具有良好的生物相容性，并具有抗氧化应激的细胞保护作用。这些发现可能为Ru NPs在相关生理条件下的应用激发新的热情。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Environmental Science and Health Part C-Environmental Carcinogenesis & Ecotoxicology Reviews 环境科学-毒理学

CiteScore

6.20

自引率

0.00%

发文量

审稿时长

>24 weeks

期刊介绍： Journal of Environmental Science and Health, Part C: Environmental Carcinogenesis and Ecotoxicology Reviews aims at rapid publication of reviews on important subjects in various areas of environmental toxicology, health and carcinogenesis. Among the subjects covered are risk assessments of chemicals including nanomaterials and physical agents of environmental significance, harmful organisms found in the environment and toxic agents they produce, and food and drugs as environmental factors. It includes basic research, methodology, host susceptibility, mechanistic studies, theoretical modeling, environmental and geotechnical engineering, and environmental protection. Submission to this journal is primarily on an invitational basis. All submissions should be made through the Editorial Manager site, and are subject to peer review by independent, anonymous expert referees. Please review the instructions for authors for manuscript submission guidance.