Cancer treatment and management for elderly patients 80 years of age or older with malignant solid tumors.

Q3 Pharmacology, Toxicology and Pharmaceutics
Mao Matsubayashi, Fumihiro Oshita, Natsuki Kawata, Takafumi Yanagibashi, Satoshi Tanaka, Yoshiteru Hao, Yuichi Kurakami, Keisuke Iwabuchi, Yohsuke Kunishi, Mitsuyasu Ohta, Yuki Nakamura, Kohichiro Yoshie
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Abstract

Objective: We retrospectively analyzed the backgrounds, treatment and nursing care for 96 patients aged 80 years or more with malignant tumors. Twenty of them were hospitalized on an emergency basis. Sixty patients were male and 36 were female, with a median age of 83 years (range: 80-94 years). Twenty-seven had a PS of 3 or 4, and 41 were rated as not independent based on analysis of autonomy at hospitalization. Forty-seven patients had clinical stage III or IV malignancies. The proportions of patients with disease complications were 33.3% for neurological disease, 21.9% for respiratory disease, 70.8% for cardiovascular disease including hypertension, and 36.5% for metabolic disease. Thirty-nine patients underwent surgical or endoscopic resection of their tumors. Twenty-three patients received chemotherapy: hormonal treatment in 14, local injection of cytotoxic agent(s) in 6 and systemic anti-cancer therapy in 3. Thirty-nine patients received supportive care only. Forty-three patients newly required nursing care or an increased level of care at discharge. The median survival time was 10.9 and 15.3 months for stage III/IV and 0/I/II patients, respectively. In conclusion, most elderly patients with malignant tumors require full supportive care, including social nursing care, from the time of cancer diagnosis.

80岁及以上老年恶性实体瘤患者的肿瘤治疗与管理。
目的:回顾性分析96例80岁以上恶性肿瘤患者的背景、治疗及护理。其中20人被紧急送往医院。男性60例,女性36例,中位年龄83岁(范围80-94岁)。27例患者的PS为3或4分,41例患者在住院时的自主性分析中被评为不独立。47例患者有临床III期或IV期恶性肿瘤。其中,神经系统疾病占33.3%,呼吸系统疾病占21.9%,包括高血压在内的心血管疾病占70.8%,代谢性疾病占36.5%。39例患者接受手术或内镜切除肿瘤。23例患者接受化疗:激素治疗14例,局部注射细胞毒药物6例,全身抗癌治疗3例。39例患者仅接受支持性治疗。43例患者在出院时需要护理或提高护理水平。III/IV期和0/I/II期患者的中位生存时间分别为10.9和15.3个月。综上所述,大多数老年恶性肿瘤患者从癌症诊断开始就需要充分的支持性护理,包括社会护理。
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