Cephalexin plus trimethoprim-sulfamethoxazole was not superior to cephalexin alone for the treatment of outpatient non-purulent cellulitis.

Evidence-Based Medicine Pub Date : 2017-12-01 Epub Date: 2017-11-10 DOI:10.1136/ebmed-2017-110796
Loren G Miller
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Abstract

Commentary on:  Moran GJ, Krishnadasan A, Mower WR, et al . Effect of cephalexin plus trimethoprim-sulfamethoxazole vs cephalexin alone on clinical cure of uncomplicated cellulitis: a randomised clinical trial. JAMA 2017;317:2088–96. Skin infections are one of the most common infections in ambulatory medicine. Yet, despite the high incidence of these infections, there remain questions about optimal treatment of cellulitis without abscess. Cellulitis without abscess is particularly challenging, as the aetiology of this infection remains relatively elusive. Studies employing molecular diagnostic techniques for bacteria from needle biopsies of cellulitis have failed to determine the aetiology of cellulitis without abscess. Current thinking is that cellulitis is usually caused by Group A Streptococcus and occasionally Staphylococcus aureus , possibly including methicillin-resistant S. aureus (MRSA). However, the relative contribution of these pathogens is unclear and the need to include anti-MRSA therapy as part of treatment for …
头孢氨苄联合甲氧苄氨苄磺胺甲恶唑治疗门诊非化脓性蜂窝织炎并不优于头孢氨苄单用。
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