Gas Chromatography Mass Spectrometry (GC-MS) for Identification of Designer Stimulants Including 2C Amines, NBOMe Compounds, and Cathinones in Urine

Hemamalini Ketha, Milad Webb, Larry Clayton, Sean Li
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引用次数: 9

Abstract

Phenethylamine derivatives are being increasingly exploited for recreational use as “designer” stimulants designed to mimic psychostimulant properties of amphetamine or other illicit substances like 3,4-methylenedioxymethamphetamine (MDMA [ecstasy]). Clandestine operations meticulously design phenethylamines so the user can bypass legal action when detected, as many of these are yet to be regulated by government authorities. Substituted phenethylamines or 2C amines, N-methoxybenzyl derivatives of the corresponding 2C amines commonly known as NBOMe compounds, and cathinones are among the most commonly abused phenethylamines. Current FDA-approved assays used in screening for illicit drug use lack the sensitivity needed to detect designer stimulants making it challenging for toxicologists to accurately identify these compounds. Gas chromatography mass spectrometry (GC-MS) is a sensitive method for identifying designer stimulants. This unit describes and compares two qualitative GC-MS methods for identifying 2C amines, NBOMe compounds, and cathinones in urine. © 2017 by John Wiley & Sons, Inc.

气相色谱-质谱法(GC-MS)鉴定尿液中包括2C胺、nbp化合物和卡西酮的设计兴奋剂
苯乙胺衍生物越来越多地被用于娱乐用途,作为“设计”兴奋剂,模仿安非他明或其他非法物质(如3,4-亚甲基二氧甲基苯丙胺(MDMA[摇头丸])的精神兴奋剂特性。秘密行动精心设计苯乙胺,以便使用者在被发现时可以绕过法律诉讼,因为其中许多尚未受到政府当局的监管。取代苯乙胺或2C胺、相应的2C胺的n -甲氧基苯基衍生物(俗称NBOMe化合物)和卡西酮是最常被滥用的苯乙胺。目前fda批准的用于筛选非法药物使用的检测方法缺乏检测设计兴奋剂所需的灵敏度,这使得毒理学家很难准确识别这些化合物。气相色谱-质谱法(GC-MS)是鉴别设计兴奋剂的灵敏方法。本单元描述并比较了两种定性GC-MS方法,用于鉴定尿液中的2C胺,nbp化合物和卡西酮。©2017 by John Wiley &儿子,Inc。
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