A Probable Case of Burn-out NASH Caused by Panhypopituitarism Secondary to Craniopharyngioma.

Yuichi Terawaki, Kunitaka Murase, Ryoko Motonaga, Makito Tanabe, Takashi Nomiyama, Satoshi Shakado, Mikiro Mizoguchi, Shotaro Sakisaka, Toshihiko Yanase
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Abstract

A 38-year-old man diagnosed with craniopharyngioma at 8 years old underwent repeated surgery and radiation therapy. Complications included panhypopituitarism including growth hormone deficiency and hypogonadism at 13 years old. At 26 years of age, a slight fatty liver was found, which finally developed into liver cirrhosis (LC) at 35 years old. Viral infection or other etiologies causing LC were negative on serum examinations. Liver biopsy suggested a possibility of burn-out non-alcoholic steatohepatitis. This case indicates that a long-standing growth hormone deficiency and hypogonadism may lead to LC as a type of burn-out non-alcoholic steatohepatitis.

继发于颅咽管瘤的全垂体功能低下引起的可能的衰竭型NASH病例。
一名38岁的男子在8岁时被诊断为颅咽管瘤,接受了多次手术和放疗。并发症包括全垂体功能低下,包括生长激素缺乏和性腺功能减退。26岁时发现轻度脂肪肝,35岁时发展为肝硬化(LC)。病毒感染或其他病因导致llc的血清检查呈阴性。肝活检提示可能为燃烧性非酒精性脂肪性肝炎。本病例提示,长期生长激素缺乏和性腺功能减退可能导致LC作为一种燃烧型非酒精性脂肪性肝炎。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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