The selective serotonin reuptake inhibitor fluoxetine increases spontaneous afferent firing, but not mechanonociceptive sensitization, in octopus.

Q4 Neuroscience

Invertebrate Neuroscience Pub Date : 2017-10-07 DOI:10.1007/s10158-017-0203-1

Paul V Perez, Hanna M Butler-Struben, Robyn J Crook

引用次数: 6

Abstract

Serotonin is a widely studied modulator of neural plasticity. Here we investigate the effect of fluoxetine, a selective serotonin reuptake inhibitor, on short-term, peripheral nociceptive plasticity in the neurologically complex invertebrate, octopus. After crush injury to isolated mantle (body wall) tissue, application of 10 nM fluoxetine increased spontaneous firing in crushed preparations, but had a minimal effect on mechanosensory sensitization. Effects largely did not persist after washout. We suggest that transiently elevated, endogenous serotonin may help promote initiation of longer-term plasticity of nociceptive afferents and drive immediate and spontaneous behaviors aimed at protecting wounds and escaping dangerous situations.

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选择性5 -羟色胺再摄取抑制剂氟西汀增加章鱼的自发传入放电，但不增加机械知觉致敏。

血清素是一种被广泛研究的神经可塑性调节剂。在这里，我们研究了氟西汀(一种选择性血清素再摄取抑制剂)对神经系统复杂的无脊椎动物章鱼短期外周伤害性可塑性的影响。在孤立的套膜(体壁)组织挤压损伤后，应用10 nM氟西汀增加了粉碎制剂中的自燃，但对机械感觉致敏的影响很小。冲洗后，效果基本上不会持续。我们认为，短暂升高的内源性血清素可能有助于促进伤害性事件的长期可塑性的启动，并驱动旨在保护伤口和逃离危险情况的即时和自发行为。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Invertebrate Neuroscience NEUROSCIENCES-

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Invertebrate Neurosciences publishes peer-reviewed original articles, reviews and technical reports describing recent advances in the field of invertebrate neuroscience. The journal reports on research that exploits the simplicity and experimental tractability of the invertebrate preparations to underpin fundamental advances in neuroscience. Articles published in Invertebrate Neurosciences serve to highlight properties of signalling in the invertebrate nervous system that may be exploited in the field of antiparisitics, molluscicides and insecticides. Aspects of particular interest include: Functional analysis of the invertebrate nervous system; Molecular neuropharmacology and toxicology; Neurogenetics and genomics; Functional anatomy; Neurodevelopment; Neuronal networks; Molecular and cellular mechanisms of behavior and behavioural plasticity.