Metabolic Correction in Patients Sample with Diabetes: Clinical Outcomes and Costs Reductions.

Jorge R Miranda-Massari, José R Rodríguez-Gómez, Michael J González, Carlos Cidre, Jorge Duconge, Heriberto Marín, Kazuko Grace, Howard L McLeod
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Abstract

Diabetes is a leading cause of mortality and morbidity worldwide. Diabetes complications produce profound impact on patient's quality of life and represent very significant economic cost to patients, their family, the government and society as a whole. Metabolic correction has been proposed as an efficient method to improve clinical outcomes and reduce costs in diabetes. Metabolic correction is a concept that supports health maintenance and promotes the healing processes by improving the body's biochemical-physiological mechanisms. This is done by helping activate the metabolic enzymes necessary to facilitate key physiological pathways. A group of 50 patients followed a simple metabolic correction strategy based on hydration, diet, and magnesium supplementation during a 6 months period. Outcomes measures included laboratory testing, anthropometric measures and medication use including its related costs. Patients had an average weight loss of 9.4 lbs (↓5.0%) from baseline at month 3 and 12 lbs (↓6.4%) at month 6. Waist circumference decreased on average 3.7 inches (↓9.0%) from baseline at month 3 and had further decrease to 5.5 inches (↓13.4%) from baseline at month 6. Laboratory testing of average triglycerides decreased from a baseline of 156.9 to 116.7 (↓25.6%) at month 3 and maintained a reduction of ↓24.2% by month 6. Total cholesterol concentration decreased from a baseline of 181.1 mg/dL to 173.9 (↓4.0%) in month 3 and to 171.1 (↓5.5%) at month 6. Average HgA1c decreased from baseline of 7.17 to 6.52 (↓9.1%) at month 3 and maintained 6.52 at months 6. The atherogenic index decreased from 4.18 at baseline to 3.85 at month 3 (↓7.9%) and then 3.47 (17.0%) at month 6. Medication use and cost was quantified in various ways. The average baseline monthly diabetes medication cost per patient of $124.10 was reduced to $ 78.23 (↓36.7% reduction) at month 3 and to $62.80 (↓49.4% reduction) at month 6. A simple and well structured metabolic correction program that includes a significant educational component, dietary modifications and dietary supplement intake was able to maintain or improve vital signs, anthopometric and laboratory measurements that correlate with improved clinical diabetes and cardiovascular health. This outcome was achieved while decreasing the use medications at month 3 and 6 at significant cost savings.

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糖尿病样本患者的代谢矫正:临床效果与成本降低。
糖尿病是全球死亡和发病的主要原因。糖尿病并发症对患者的生活质量产生深远影响,并给患者及其家庭、政府和整个社会带来巨大的经济损失。新陈代谢矫正被认为是改善糖尿病临床疗效和降低成本的有效方法。代谢矫正是一种通过改善人体生化生理机制来支持健康维护和促进治疗过程的概念。具体做法是帮助激活促进关键生理途径所需的代谢酶。一组 50 名患者在 6 个月的时间里遵循了基于水合、饮食和镁补充的简单代谢纠正策略。结果测量包括实验室检测、人体测量和药物使用(包括相关费用)。患者的体重在第 3 个月比基线平均减轻了 9.4 磅(↓5.0%),在第 6 个月比基线平均减轻了 12 磅(↓6.4%);腰围在第 3 个月比基线平均减少了 3.7 英寸(↓9.0%),在第 6 个月比基线进一步减少到 5.5 英寸(↓13.4%)。实验室检测的甘油三酯平均值在第 3 个月从基线值 156.9 降至 116.7(↓25.6%),并在第 6 个月保持↓24.2%的降幅。 总胆固醇浓度在第 3 个月从基线值 181.1 毫克/分升降至 173.9(↓4.0%),在第 6 个月降至 171.1(↓5.5%)。平均 HgA1c 从基线的 7.17 降至第 3 个月的 6.52(↓9.1%),第 6 个月维持在 6.52。每位患者每月平均糖尿病药物费用基线为 124.10 美元,第 3 个月时降至 78.23 美元(降幅为 36.7%),第 6 个月时降至 62.80 美元(降幅为 49.4%)。 一项简单而结构合理的代谢矫正计划,包括重要的教育内容、饮食调整和膳食补充剂摄入,能够维持或改善生命体征、人体测量和实验室测量结果,这与临床糖尿病和心血管健康的改善相关。在取得这一成果的同时,第 3 个月和第 6 个月的用药量也有所减少,大大节约了成本。
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