Arshag D. Mooradian, Jason M. Held, Kristen M. Naegle
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引用次数: 5
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Abstract
Post-translational modifications (PTMs) of protein amino acids are ubiquitous and important to protein function, localization, degradation, and more. In recent years, there has been an explosion in the discovery of PTMs as a result of improvements in PTM measurement techniques, including quantitative measurements of PTMs across multiple conditions. ProteomeScout is a repository for such discovery and quantitative experiments and provides tools for visualizing PTMs within proteins, including where they are relative to other PTMS, domains, mutations, and structure. ProteomeScout additionally provides analysis tools for identifying statistically significant relationships in experimental datasets. This unit describes four basic protocols for working with the ProteomeScout Web interface or programmatically with the database download. © 2017 by John Wiley & Sons, Inc.
使用ProteomeScout:翻译后修饰的资源，他们的实验，和他们注释的蛋白质
蛋白质氨基酸的翻译后修饰(PTMs)普遍存在，对蛋白质的功能、定位、降解等都很重要。近年来，由于PTM测量技术的改进，包括在多种条件下对PTM的定量测量，PTM的发现出现了爆炸式增长。ProteomeScout是此类发现和定量实验的存储库，并提供了可视化蛋白质内PTMs的工具，包括它们相对于其他PTMs，结构域，突变和结构的位置。ProteomeScout还提供了分析工具，用于识别实验数据集中的统计显著关系。本单元描述了使用ProteomeScout Web界面或以编程方式使用数据库下载的四种基本协议。©2017 by John Wiley &儿子,Inc。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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